Principal Investigator

10-3009-PHARMAHEAD_Ikezu-116Tsuneya Ikezu, MD/PhD
Awarded Alzheimer’s Art Quilt Institute 2013 Research award

Research Staff

IkezuSeiko1-150x150Seiko Ikezu, MD – Senior Scientist
Research: Seiko’s research is focused on genetic and pharmacological modulation of protein kinases, namely tau-tubulin kinases(TTBK), which are  involved in aggregation of neuropathogenic protein, such as microtubule-associated protein tau, alpha-synuclein, and TDP-43.  Phosphorylation of the amyloidgenic proteins are found in the Ubiquitin-positive inclusion bodies of Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease and amyotrophic lateral sclerosis. TTBK1 and 2 are potential therapeutic target of the proteinopathy-related neurodegeneration.
DSC_5178-Hirohide-Asai1-150x150Hirohide Asai, MD/PhD, Postdoctoral Fellow
Research: Hiro is studying the molecular mechanism of axonal degeneration and tauopathy development in transgenic mouse models of Alzheimer’s disease.Updates: Received BrightFocus Foundation 2013 Research Award for Alzheimer’s DiseaseUpdates: Selected for oral presentation at 11th Annual BU Alzheimer’s Disease Research Day

Graduate Students

MVarnum-150x150Megan Varnum (PhD student, Program in Biomolecular Pharmacology)
Research: Megan’s research focuses on Traumatic Brain Injury (TBI) using the blast mouse models and investigate the role of the inflammation and behavioral deficits. She is also working on the role of CD200 in Alzheimer’s disease. Megan recently authored a review article on microglial activation phenotypes on neurodegenerative disorders.
maya_woodbury_portrait-150x150Maya Woodbury PhD student, Graduate Program for Neuroscience/Program in Biomolecular Pharmacology
Research: Maya is studying the molecular characterization of growth factors and glia-derived cytokines and their effect on neuronal development, especially focusing on Autism Spectrum Disorders and Down Syndrome.Updates: Received PhRMA Foundation 2014 Pre Doctoral Fellowship in Pharmacology & Toxicology

Undergraduate Students

LacinLacin Koro (BU Neuroscience Major)
 Received Howard Hughes Medical Institute Summer Research Scholarship
 Received the Howard Hughes Medical Institute travel award for the Society for Neuroscience meeting

IMG_1571Grant Yonemoto (BU Biology Major)
Updates: Received UROP research award for 2013 summer
 Co-authored in Am J Pathol. 2014 Mar;184(3):808-18


Ingraham-KatieKaitlin Ingraham, BA
Kaitlin was accepted into the UCLA Graduate ACCESS Program.
DSC_5183-Rob-Freilich1-150x150Robert W. Freilich (MD/PhD student)
Research: Rob’s research is aimed at understanding how microRNAs influence the neuroimmune response in the CNS, focused specifically on microglia and on inflammatory regulation of adult hippocampal neurogenesis.Updates: Received PhRMA Foundation 2012 Paul Calabresi Medical Student Fellowship

Updates: Received 2013 Henry I. Russek Student Achievement First Prize

Updates: Successfully defended thesis in May 2013

tessaTessa Abagis, BA
Tessa completed honors thesis study at BU and is currently Clinical Research Assistant in the Depression Center at University of Michigan. Tessa has been working on a project entitled “Imaging biomarkers for transcranial magnetic stimulation treatment of depression.”

JDBJonathan Boucher, BS

Jonathan completed multiple UROPs in Ikezu lab, graduated BU in 2014, and joins Dr. Greco lab at Department of Genetics and Dermatology, Yale University as a research technician.