Publications

Kostakis E, Jang M-K, Russek SJ, Gibbs TT, Farb DH (2011) A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons. J. Neurochemistry, in press.

Kostakis E*, Jang M-K*, Martin SC, Zhong H, Richards K, Russek SJ, Gibbs TT† Farb DH† (2011) Pregnenolone Sulfate Induces NMDA Receptor Dependent G-Protein Coupled Insertion of NMDA Receptors into the Plasma Membrane. J. Neuroscience, in revision. (equal contributions: * and †).

S. Desbiens and D.H. Farb (2011) Medicine and Pathology – Current Needs for New Therapeutic Agents and Discovery Strategies – A Systems Pharmacology Approach. In: Development of Therapeutic Agents (Shayne Gad, Ed.) John Wiley & Sons.

Oblak AL, Gibbs TT, Blatt GJ. Reduced GABA(A) receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2010 Sep 19. [Epub ahead of print] [Abstract]

Sadri-Vakili. G., V. Kumaresan, H.D.Schmidt, K.R. Famous, P. Chawla, F.Vassoler, R.Overland, E.Xia, C.E.Bass, E.Terwilliger, R.C.Pierce and J-H. Cha (2010).Cocaine-induced chromatin remodeling increases BDNF transcription in the medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. Journal of Neuroscience 30 (35): 11735-11744.

Oblak AL, Gibbs TT, Blatt GJ. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J Neurochem. 2010 Sep 1;114(5):1414-23. Epub 2010 Jun 12. [Abstract]

K.L. Eagleson, M.C. Gravielle, L.J. Schlueter McFadyen-Ketchum, S.J. Russek, D.H. Farb, and P. Levitt. (2010) Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes. Neuroscience 2010 Jul 14; 168(3):797-810.

J.H. Kim, D.H. Farb, and S.J. Russek, (2009) Promoter. Encyclopedia of Neuroscience. U. Windhorst, M.D. Binder, N. Hirokawa, and M.C. Hirsch, Editors. Springer Publishing, Heidelberg, Germany. Part 16, pp. 3291 – 3294.

Kumaresan.V, Y. Menglu, J.Yee, H.D. Schmidt, K.R. Famous, and R.C. Pierce (2009). Role of nucleus accumbens metabotropic glutamate receptors (mGluR5) in the reinstatement of cocaine-seeking Behavioral Brain Research 202:238-244. PMCID: PMC2844436

D. Berezhnoy, T.T. Gibbs, and D.H. Farb. (2009) Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site. Mol Pharmacol 2009 Aug; 76(2):440-50. [Full Text]

Oblak, A., Gibbs, T.T., and Blatt, G.J. (2009) Decreased GABA(A) receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Res 2009 Jul 31. [Full Text]

Berezhnoy, D, Gibbs, TT, and Farb, DH (2009) Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site. Mol Pharmacol 76:440-450. PMID: 19483108 [ Abstract]

Sadri-Vakili G, Janis GC, Pierce RC, Gibbs TT, Farb DH. Nanomolar Concentrations of Pregnenolone Sulfate Enhance Striatal Dopamine Overflow In Vivo. J Pharmacol Exp Ther. 2008 Sep 4. PMID: 18772319 [Full Text]

Famous, K.R., V. Kumaresan, G. Sadri-Vakili, H.D. Schmidt, D.F. Mierke, J.-H.J. Cha and R.C. Pierce. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens shell contributes to the reinstatement of cocaine seeking. Journal of Neuroscience 2008, 28 (43): 11061-1170. PMCID: PMC2601563.

Anderson, S.M., *K.R. Famous, *G. Sadri-Vakili, *V. Kumaresan, H.D. Schmidt, C. Bass, E. Terwilliger, J.-H.J. Cha and R.C. Pierce (2008). Calcium/calmodulin-dependent protein kinase II(CaM-KII): the biochemical bridge linking nucleus accumbens dopamine and glutamate systems in the reinstatement of cocaine seeking. Nature Neuroscience 11(3):344-353
*(denotes co-first authors).

Whittaker MT, Gibbs TT, Farb DH. Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum. J Neurochem. 2008 Aug 14. PMID: 18710414 [Full Text]

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. BMC Pharmacol. 2008 Jun 13;8:11. PMID: 18554397 [Full Text]

Y. Hu, I. V Lund, M. C. Gravielle, D. H. Farb, A. R. Brooks-Kayal, and S. J. Russek (2008) Surface expression of GABA(A) receptors is transcriptionally controlled by the interplay of CREB and its binding partner ICER. J. Biol. Chem. Apr 4; 283 (14):9328-40. Jan 7; Epub 2008 Jan 7.

D. Berezhnoy, M.C. Gravielle, and D.H. Farb (2007) Pharmacology of the GABAA Receptor, In: Handbook of Contemporary Neuropharmacology (David Sibley, Michael Kuhar, Israel Hanin, and Phil Skolnick, Eds.) John Wiley & Sons.

D.H. Farb, J.L. Steiger, S.C. Martin, M.C. Gravielle, T.T. Gibbs, and S.J. Russek (2007) Mechanisms of GABAA and GABAB Receptor Gene Expression In: The GABA Receptors (Sam Enna and Hans Mohler, Eds.) Humana Press.

Guptill JT, Booker AB, Gibbs TT, Kemper TL, Bauman ML, Blatt GJ. [³H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord. 2007 May;37(5):911-20. [Abstract]

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13. [Full Text]

Gibbs TT, Russek SJ, Farb DH. Sulfated steroids as endogenous neuromodulators. Pharmacol Biochem Behav. 2006 Aug;84(4):555-67. Epub 2006 Oct 4. [Abstract]

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methan one (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13. [Abstract]

Pierce, R.C. and V. Kumaresan (2006). The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neuroscience and Biobehavioral Reviews 30:216-238.

Downing SS, Lee YT, Farb DH, Gibbs TT. Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation. Br J Pharmacol. 2005 Aug;145(7):894-906. [Abstract]

Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. (2005) Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. Epub 2005 May 3. [Abstract]

Gravielle MC, Faris R, Russek SJ, Farb DH. (2005) GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons. J Biol Chem. 2005 Jun 3;280(22):20954-60. Epub 2005 Apr 1. [Abstract]