People

10-3061-PHARMALABS-0101

Principal Investigator

FARB David H. Farb, Ph.D., Professor and Chairman of Pharmacology
As head of the Laboratory of Molecular Neurobiology, he focuses on the identification of pharmacological treatments for mental disorders of learning and memory. His research integrates existing electrophysiological, behavioral, pharmacological, and molecular genetic technologies in a novel systems-level platform for assessing the impact of cognitive enhancers such as neuroactive steroids upon fundamental hippocampal systems for pattern separation (encoding), and pattern completion (retrieval) that are believed to be essential for cognition in all mammals, including man.

     

    Senior Laboratory Staff

    DowningScott-150x150 Scott Downing, Ph.D., Bioinformatics Research
    Scientist
    10-3009-PHARMAHEAD_Kumaresan-015-150x150 Vidhya Kumaresan, Ph.D., Research Assistant Professor

      10-3061-PHARMALABS-0092 Marcia Ratner, Ph.D., Project Manager

         

        Graduate Students

        Sugunan Image Kavitha Sugunan, Ph.D. candidate, Program in Biomolecular Pharmacology/ Program in Biomedical Neuroscience

           

          Recent Alumni

          IMAG0356 Conor Smith, Ph.D., Program in Biomolecular Pharmacology/ Program in Biomedical Neuroscience, 2014.

          Congratulations Conor!

            TStewart[2] Tara Stewart, Ph.D., Program in Biomolecular Pharmacology/ Program in Biomedical Neuroscience, 2014.

            Congratulations T!

              Undergraduate Students

              920198_10200832613447952_1942573613_o John Morgan Adams, majoring in Neuroscience with a minor in Chemistry.

              John currently works with Kavitha on the image analysis portion of her pregnenolone sulfate project, and is working with her on bench work in preparation for his more hands on assistance with the project in the Summer of 2014.

                Screen Shot 2014-04-22 at 12.39.54 PM Ryan BadolatoGraduate of BU with a degree in Neuroscience with a minor in Chemistry 2014.  Congratulations Ryan!

                Ryan is enjoying a gap year before applying to medical school.  He is currently a Research Assistant in the LMN where he is investigating the effects of pregnenolone sulfate on protein phosphorylation and calcium influx in cortical neurons.

                Unknown Lauren Baltrus, majoring in Neuroscience
                Lauren received funding through the Howard Hughes Medical Institute. She  is working with the in vivo electrophysiology team under the direct supervision of Dr. Marcia Ratner studying the effects of neuroactive steroids on neural network activity..
                Zach Bogart Zach Bogart, majoring in Neuroscience with a minor in Computer Science
                Zach’s work involves using implanted microelectrode microarrays to record from neurons in the hippocampus of freely behaving rodents.  The primary objective of his research is to study how drugs known to improve learning and memory influence the activity of hippocampal places cells.  He received funding through the Howard Hughes Medical Institute during his freshman year and completed a Directed Study under Dr. Ratner. He is currently taking a semester off to study abroad.
                2 Kayla Duval,majoring in Biomedical Engineering
                Kayla works with Dr. Vidhya Kumaresan doing spine density and puncta image analyses.

                  Castro Ana Castro Sanchez, majoring in Neuroscience/Public Health
                  Ana is currently on working with the in vivo electrophysiology team under the direct supervision of Dr. Marcia Ratner.
                  LMN headshot

                  Syona Shetty, majoring in Neuroscience

                  Syona was awarded HHMI funding in the summer of 2013 to study the effects of pregnenolone sulfate on NMDA receptor distribution in rat hippocampal neurons.  This summer, under UROP funding, she will use immunocytochemistry and Western blot experimentation to study the downstream proteins that pregnenolone sulfate interacts with to produce the changes observed last summer.

                  2014-04-18 12.41.48 Mateo Zambrano, majoring in Neuroscience with a minor in Public Health

                  In the summer of 2013, funded by the HHMI grant, Mateo did research on the effects of pregnenolone sulfate on synaptic plasticity. He studied the effects of the steroid on dendritic spine density and morphology.

                  This summer, funded by UROP, he will study the effect of pregnenolone sulfate on the internal calcium levels of in vitro rat cortical neurons through calcium imaging.

                  Alexia Maliakal, majoring in Biochemistry and Molecular Biology

                  She is working with the in vivo electrophysiology group under the supervision of Dr. Marcia Ratner studying the effects of neuroactive steroids on neural network activity.