|David H. Farb, Ph.D., Professor and Chairman of Pharmacology
As head of the Laboratory of Molecular Neurobiology, he focuses on the identification of pharmacological treatments for mental disorders of learning and memory. His research integrates existing electrophysiological, behavioral, pharmacological, and molecular genetic technologies in a novel systems-level platform for assessing the impact of cognitive enhancers such as neuroactive steroids upon fundamental hippocampal systems for pattern separation (encoding), and pattern completion (retrieval) that are believed to be essential for cognition in all mammals, including man.
Senior Laboratory Staff
|Scott Downing, Ph.D., Bioinformatics Research Scientist|
|Vidhya Kumaresan, Ph.D., Research Assistant Professor
|Marcia Ratner, Ph.D., Project Manager
Dr. Ratner is the senior member of the in vivo electrophysiology team which is investigating how drugs alter learning and memory function in freely behaving rodents. The major advantage of in vivo electrophysiology over other functional measures of neural activity such as regional cerebral blood flow is in the ability of this technology to differentiate the activity of inhibitory interneurons from that of excitatory pyramidal cells both across brain regions and within subregions. This highly translational approach is well suited for target-based as well as repurposing studies of drug-induced changes in both single unit activity and local field potentials.
|Ryan Badolato, Research Technician
Ryan earned his bachelors degree in Neuroscience from Boston University where he was a member of Phi Beta Kappa. Ryan’s work focuses on determining the mechanism and molecular consequences of neuroactive steroid application in cultured cortical neurons. Ryan has played a key role in our studies of how neuroactive steroids modulate calcium signaling. His work is helping to advance our understanding of the role neuroactive steroids play in modulating neural network activity and how these compounds can be used to treat cognitive disorders.
Post Doctoral Fellows