|David H. Farb, Ph.D., Professor and Chairman of Pharmacology
As head of the Laboratory of Molecular Neurobiology, he focuses on the identification of pharmacological treatments for mental disorders of learning and memory. His research integrates existing electrophysiological, behavioral, pharmacological, and molecular genetic technologies in a novel systems-level platform for assessing the impact of cognitive enhancers such as neuroactive steroids upon fundamental hippocampal systems for pattern separation (encoding), and pattern completion (retrieval) that are believed to be essential for cognition in all mammals, including man.
Senior Laboratory Staff
|Scott Downing, Ph.D., Bioinformatics Research Scientist
Dr. Downing is an experienced computer programmer who works closely with Dr. Ratner to develop the computer codes used for analysis of our in-vivo electrophysiological data. He has written specialized codes to permit parallel processing of large data sets via an unsupervised machine learning technique. These codes facilitate efficient auto-sorting of waveforms into “clusters” of action potentials derived from a single neuron for subsequent statistical analysis.
|Vidhya Kumaresan, Ph.D., Research Assistant Professor
Dr. Kumaresan’s overall research objective is to study neuronal activity-dependent plasticity and its relevance for learning, memory and pathological plasticity under pinning brain disorders. She collaborates with Dr. Farb in elucidating neuronal plasticity elicited by neurosteroids. The major focus of Dr. Kumaresan’s research is to understand the neurobiological bases of addiction to psychostimulants. Dr. Kumaresan employs a novel approach of using cell-permeable peptides that disrupt protein-protein interactions in vivo in order to study ongoing behavior. Knowledge gained from these studies will also be applicable to the treatment of other brain dysfunctions involving persistent memories such as PTSD.
|Marcia Ratner, Ph.D., Project Manager
Dr. Ratner is the senior member of the in vivo electrophysiology team which is investigating how chemicals alter learning and memory function in freely behaving rodents. The major advantage of in vivo electrophysiology over other functional measures of neural network activity such as regional cerebral blood flow is in the ability of this technology to effectively differentiate the activity of inhibitory interneurons from that of excitatory pyramidal cells both across brain regions and within subregions. This highly translational approach to drug discovery is well suited for target-based as well as repurposing studies of drug-induced changes in both single unit activity and local field potentials.
Kavitha Sugunan, Ph.D. candidate, Program in Biomolecular Pharmacology/ Program in Biomedical Neuroscience 2015. Congratulations Kavitha! Kavitha is employed at ClinTec International.