Laboratory for Cardiovascular-Renal Research
Our laboratory focuses on the central neural control of fluid and electrolyte homeostasis and blood pressure regulation. We have identified a novel brain G-alpha-i2 subunit protein-gaged pathway that is essential to mediate endogenous GPCR-activated pathways that regulate central sympathetic outflow, fluid and electrolyte homeostasis, and systemic blood pressure regulation.
There are several ongoing projects within the laboratory:
- The role of PVN specific G-alpha subunit protein gated pathways in mediating the neural control of kidney function via the renal sympathetic nerves
- The role of PVN specific G-alpha subunit protein gated pathways in sodium activated neuronal activity and systemic arterial blood pressure regulation in salt-resistant vs. salt-sensitve phenotypes
- The role of enhanced sympathetic outflow and sodium intake on the expression and activity of renal sodium transporters in salt-resistant vs. salt-sensitve phenotypes
Recent Lab News
- Richard Wainford receives 2013 Endocrine Society New Early Investigator Award (June 15)
- Richard Wainford selected as finalist for American Heart Association Council on High Blood Pressure Harry Goldblatt Award.
- Richard Wainford Elected as Early Career Member of the American Heart Association Council on High Blood Pressure Leadership Council (Term 2013-2016).