Selected Publications
Lund IV, Hu Y, Yogendra SHR, Benham RS, Faris R, Russek SJ , Brooks-Kayal AR. BDNF Selectively Regulates GABA-A A Receptor Transcription by Activation of the JAK/STAT Pathway. Science Signaling. 2008 October; 1(41): 1-14.
Hu Y, Russek SJ. BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation. J Neurochem. 2008 Apr; 105(1): 1-17. Epub 2008 Jan 18. Review.
Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ. Surface expression of GABA (A) receptors is transcriptionally controlled by the interplay of CREB and its binding partner ICER. J Biol Chem. 2008 Apr 4; 283(14):9328-40. Epub 2008 Jan 7.
Reddy TE, Shakhnovich BE, Roberts DS, Russek SJ, DeLisi C.. Positional clustering improves computational binding site detection and identifies novel cis-regulatory sites in mammalian GABAA receptor subunit genes. Nucleic Acids Res. 2007;35(3):e20. Epub 2007 Jan 3.
Raol YH, Lund IV, Bandyopadhyay S, Zhang G, Roberts DS, Wolfe JH, Russek SJ, Brooks-Kayal AR. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci. 2006 Nov 1;26(44):11342-6.
Roberts DS, Hu Y, Lund IV, Brooks-Kayal AR, Russek SJ. Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. J Biol Chem. 2006 Oct 6;281(40):29431-5. Epub 2006 Aug 10.
Roberts DS, Raol YH, Bandyopadhyay S, Lund IV, Budreck EC, Passini MJ, Wolfe JH, Brooks-Kayal AR, Russek SJ. (2005) Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABAA receptor {alpha}4 subunit expression. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11894-9. Epub 2005 Aug 9. [Abstract ]
Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. (2005) Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. Epub 2005 May 3. [ Abstract ]
Gravielle MC, Faris R, Russek SJ, Farb DH. (2005) GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons. J Biol Chem. 2005 Jun 3;280(22):20954-60. Epub 2005 Apr 1. [ Abstract ]
Steiger JL, Bandyopadhyay S, Farb DH, Russek SJ. (2004) cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters. J Neurosci. 2004 Jul 7;24(27):6115-26. [ Abstract ]
