Selected Publications

Flynn R L, Chang S, and Zou L. RPA and POT1: Friends or foes at telomeres? Cell Cycle. 2012 Feb 15;11(4):652-7.

Flynn R L, Centore, RC,  O’Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, and Zou L. TERRA and hnRNPA1 Orchestrate an RPA-to-POT1 Switch on Telomeric Single-Stranded DNA. Nature. 2011 Mar 24;471(7339):532-6

Flynn R L and Lee Zou ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci. 2011 Mar;36(3):133-40.

Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell. 2010 Oct 8;40(1):22-33

Flynn RL, Zou L. Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol. 2010 Aug;45(4):266-75

Xie Jenny, *Flynn R L, Wang S, Peng M, Guillemette S, Rooney T, and Cantor S B,.Targeting the FANCJ-BRCA1 interaction reveals mechanistic insight into the switch between recombination and polh bypass pathways.  Oncogene. 2010 Apr 29;29(17):2499-508.*Co-First Author

Litman R, Gupta R, Brosh RM Jr, Cantor SB. BRCA-FA pathway as a target for anti-tumor drugs. Anticancer Agents Med Chem. (2008) 8(4):426-30.

Peng M, *Litman R, Xie J, Sharma S, Brosh RM, Cantor SB. The FANCJ/MutLa interaction is required for correction of the cross-link response in FA-J cells. EMBO J (2007) 11;26(13):3238-49 *Co-First Author

Peng, M., *R. Litman, Z. Jin, G. Fong and S.B. Cantor. BACH1 is a DNA repair protein supporting BRCA1 damage response. Oncogene (2006) 25, 2245–2253.*Co-First Author

Litman, R., M. Peng, Z. Jin, F. Zhang, J. Zhang, S. Powell, P.R. Andreassen, and S.B. Cantor. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell , Vol 8, 255-265 (2005)