Laboratory of Brain Genomics

PI: Alan Herbert, Mb.ChB., Ph.D.

It is now possible to examine at a genome-scale level how genetic variation in human alters risk of disease, either directly or through secondary risk factors such as obesity. The high resolution of the genomic approaches allows particular chromosomal regions to be identified for further study so that the pathways involved can be defined and drugable components identified. Our work uses information from high-density genotyping and expression arrays combined with massively-parallel sequencing to examine variations associated with obesity and brain development with a particular emphasis on schizophrenia. A central concern is how information is processed, whether from genomic transcripts or through neuronal arrays.

AlignmentofDNA&RNA
Figure 1: Alignment of DNA and RNA sequences from Brain

coRNA

Figure 2: Role of Co-regulatory RNAs in phenotype Nature Genetics 36:19-25 (2004)

DNAZalpha

Figure 3: Z-DNA interaction with the Zα domain of the double-strand RNA editing enzyme ADAR1 Science 284, 1841-1845 (1999)

Heterokaryon
Figure 4: Heterokaryon analysis of RNA editing.  Mol Cell 10, 1235-46 (2002).