Richard D. Wainford, Ph.D.

2012-11-08 12.22.56 Wainford 2 Blue Wall
Associate Professor of Pharmacology and Medicine, Section of Cardiovascular Medicine and Member, The Whitaker Cardiovascular Institute
Department of Pharmacology

Ph.D.: The University of Aberdeen, Aberdeen, Scotland

Principal Investigator: Laboratory for Cardiovascular-Renal Research

Research Interests

Dr. Wainford is the director of the Laboratory of Cardio-Renal Research. Dr. Wainford’s research interests focus on the central neural control of fluid and electrolyte homeostasis and blood pressure regulation. Dr. Wainford’s laboratory utilizes an integrated physiological, pharmacological, molecular, and gene-targeting approach to investigate the anti-hypertensive role(s) of central G-alpha-subunit proteins in the endogenous GPCR-activated pathways that regulate central sympatheticoutflow, fluid and electrolyte homeostasis, and systemic blood pressure regulation in salt-resistant and salt-sensitive animal models.The major goal of Dr. Wainford’s research is identifying the underlying pathophysiology of and potential treatments for hypertension. Current studies concern the role of central G-alpha subunit protein gated pathways in mediating the neural control of kidney function and systemic arterial blood pressure.

Wainford RD, Pascale CL. Kuwabara JT. Brain Gαi2-subunit protein-gated pathways are required to mediate the centrally evoked sympathoinhibitory mechanisms activated to maintain sodium homeostasis. J Hypertens 2013 Apr;(31(4):747-57. PMID:23391983. .

Kapusta DR, Pascale CL, Kuwabara JT, Wainford RD. Central nervous system Gαi2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway. Hypertension. 2013 Feb;61(2):368-75. PMID: 23213191/PMCID:PMC3562703 .

Kapusta DR, Pascale CL, Wainford RD. Brain heterotrimeric Gαi2-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress. FASEB J. 2012 Jul;26(7):2776-87. PMC3382099. Abstract .

Yosida T, Semprun-Prieto L, Wainford RD, Sukhanov S, Kapusta DR, Delafontain P. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology 2012 Mar; 153(3):1411-20. PMC3281527. Full article .

Wainford RD, Kapusta DR. Functional selectivity of central Gα-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central α(2) -adrenoceptor activation in vivo. Abstract: .

Wainford RD, Kapusta DR. Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats. Endocrinology 2010 Nov;151(11):5403-14. PMC2954710. Full article .

Wainford RD, Weaver RJ, Hawksworth GM. The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures. Toxicol In Vitro. 2009 Aug;23(5):780-8. Abstract .

Wainford RD, Kapusta DR. Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system. Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R280-8. PMC 2643980. Full article .

Wainford RD, Weaver RJ, Stewart KN, Brown P, Hawksworth GM. Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway. Toxicology. 2008 Jul 30;249(2-3):184-93. Abstract .

Wainford RD, Kurtz K, Kapusta DR. Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R535-42. PMC2519935. Full article .

Rizzi A, Spagnolo B, Wainford RD, Fischetti C, Guerrini R, Marzola G, Baldisserotto A, Salvadori S, Regoli D, Kapusta DR, Calo G. Peptides. 2007 Jun;28(6):1240-51. PMC1975813. Full article: .

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