Terrell T. Gibbs, Ph.D.

gibbs_2006Associate Professor
Department of Pharmacology

Research Interests

Dr. Gibbs’ research efforts focus on the pharmacology of neurotransmitters and neuromodulators, and on mechanisms of modulation and regulation of neurotransmitter receptor function, including up-regulation, down-regulation, desensitization, and tolerance. Current studies concern the acute and chronic effects of modulators of amino acid receptor function, including benzodiazepines, barbiturates, and steroids. Computational and electrophysiological methods are used to evaluate thermodynamically plausible models for receptor function. Trainees will be involved in the design and execution of pharmacological experiments, and will be trained in the use of radioligand and/or electrophysiological techniques of studying receptor function.

Laboratory: Lab of Molecular Neurobiology

Selected Publications

Oblak AL, Gibbs TT, Blatt GJ. Reduced GABA(A) receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2010 Sep 19. [Epub ahead of print] [Abstract]

Oblak AL, Gibbs TT, Blatt GJ. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J Neurochem. 2010 Sep 1;114(5):1414-23. Epub 2010 Jun 12. [Abstract]

Oblak, A., Gibbs, T.T., and Blatt, G.J. (2009) Decreased GABA(A) receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Res 2009 Jul 31. [ Full Text]

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. BMC Pharmacol. 2008 Jun 13;8:11. PMID: 18554397 [ Full Text ]

Sadri-Vakili G, Janis GC, Pierce RC, Gibbs TT, Farb DH. Nanomolar Concentrations of Pregnenolone Sulfate Enhance Striatal Dopamine Overflow In Vivo. J Pharmacol Exp Ther. 2008 Sep 4. PMID: 18772319 [ Full Text ]

Whittaker MT, Gibbs TT, Farb DH. Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum. J Neurochem. 2008 Aug 14. PMID: 18710414 [ Full Text ]

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. BMC Pharmacol. 2008 Jun 13;8:11. PMID: 18554397 [ Full Text ]

Guptill JT, Booker AB, Gibbs TT, Kemper TL, Bauman ML, Blatt GJ. [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord. 2007 May;37(5):911-20. [ Abstract ]

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13. [ Full Text ]

Gibbs TT, Russek SJ, Farb DH. Sulfated steroids as endogenous neuromodulators. Pharmacol Biochem Behav. 2006 Aug;84(4):555-67. Epub 2006 Oct 4. Review. [ Full Text ]

Downing SS, Lee YT, Farb DH, Gibbs TT. (2005) Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABAA receptors supports an allosteric model of modulation. Br J Pharmacol. 2005 Aug;145(7):894-906. [ Full Text ]

Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. (2005) Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. Epub 2005 May 3. [ Full Text ]

Sadri-Vakili G, Johnson DW, Janis GC, Gibbs TT, Pierce RC, Farb DH. (2003) Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate. J Neurochem. 2003 Jul;86(1):92-101. [ Abstract ]

Malayev A, Gibbs TT, Farb DH. (2002) Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids. Br J Pharmacol. 2002 Feb;135(4):901-9. [ Full Text ]

Gibbs TT, Farb DH. (2000) Dueling enigmas: neurosteroids and sigma receptors in the limelight. Sci STKE. 2000 Nov 28;2000(60):PE1. Review. [ Abstract ]

Lyons HR, Land MB, Gibbs TT, Farb DH. (2001) Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. J Neurochem. 2001 Sep;78(5):1114-26. [ Abstract ]

Weaver CE, Land MB, Purdy RH, Richards KG, Gibbs TT, Farb DH. (2000) Geometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca(2+) accumulation and cell death. J Pharmacol Exp Ther. 2000 Jun;293(3):747-54. [ Full Text ]

Lyons HR, Gibbs TT, Farb DH. (2000) Turnover and down-regulation of GABA(A) receptor alpha1, beta2S, and gamma1 subunit mRNAs by neurons in culture. J Neurochem. 2000 Mar;74(3):1041-8. [ Abstract ]

Park-Chung M, Malayev A, Purdy RH, Gibbs TT, Farb DH. (1999) Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res. 1999 May 29;830(1):72-87. [ Abstract ]

Weaver CE Jr, Wu FS, Gibbs TT, Farb DH. (1998) Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons. Brain Res. 1998 Aug 24;803(1-2):129-36. [ Abstract ]

Yaghoubi N, Malayev A, Russek SJ, Gibbs TT, Farb DH. (1998) Neurosteroid modulation of recombinant ionotropic glutamate receptors. Brain Res. 1998 Aug 24;803(1-2):153-60. [ Abstract ]

Park-Chung M, Wu FS, Purdy RH, Malayev AA, Gibbs TT, Farb DH. (1997) Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids. Mol Pharmacol. 1997 Dec;52(6):1113-23. [ Abstract ]

Weaver CE Jr, Park-Chung M, Gibbs TT, Farb DH. (1997) 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res. 1997 Jul 4;761(2):338-41. [ Abstract ]

Farb, D.H. and T.T. Gibbs (1996) Steroids as Modulators of Amino Acid Receptor Function. CRC Press 2:23-36.

Friedman LK, Gibbs TT, Farb DH. (1996) gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture. Brain Res. 1996 Jan 22;707(1):100-9. [ Abstract ]

Gyenes M, Wang Q, Gibbs TT, Farb DH. (1994) Phosphorylation factors control neurotransmitter and neuromodulator actions at the gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1994 Sep;46(3):542-9. [ Abstract ]

Park-Chung, M., F-S. Wu and D.H. Farb (1994) 3a-Hydroxy-5b-pregnan-20-one Sulfate: A Negative Modulator of the NMDA-Induced Current in Cultured Neurons. Mol. Pharmacol. 45:146-150. [ Abstract ]

Wu FS, Gibbs TT, Farb DH. (1993) Dual activation of GABAA and glycine receptors by beta-alanine: inverse modulation by progesterone and 5 alpha-pregnan-3 alpha-ol-20-one. Eur J Pharmacol. 1993 Aug 15;246(3):239-46. [ Abstract ]

Friedman L, Gibbs TT, Farb DH. (1993) Gamma-aminobutyric acidA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. Mol Pharmacol. 1993 Jul;44(1):191-7. [ Abstract ]

Farb DH, Gibbs TT, Wu FS, Gyenes M, Friedman L, Russek SJ. (1992) Steroid modulation of amino acid neurotransmitter receptors. Adv Biochem Psychopharmacol. 1992;47:119-31. No abstract available. [ Abstract ]

Celentano JJ, Gyenes M, Gibbs TT, Farb DH. (1991) Negative modulation of the gamma-aminobutyric acid response by extracellular zinc. Mol Pharmacol. 1991 Nov;40(5):766-73. [ Abstract ]

Wu FS, Gibbs TT, Farb DH. (1991) Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol. 1991 Sep;40(3):333-6. [ Abstract ]

Borden LA, Gibbs TT. (1990) Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA. Eur J Pharmacol. 1990 Jun 12;188(6):391-7. [ Abstract ]

Wu FS, Gibbs TT, Farb DH. (1990) Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone. Mol Pharmacol. 1990 May;37(5):597-602. [ Abstract ]

Roca DJ, Schiller GD, Friedman L, Rozenberg I, Gibbs TT, Farb DH. (1990) gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Mol Pharmacol. 1990 May;37(5):710-9. [ Abstract ]

Farrant M, Gibbs TT, Farb DH. (1990) Molecular and cellular mechanisms of GABA/benzodiazepine-receptor regulation: electrophysiological and biochemical studies. Neurochem Res. 1990 Feb;15(2):175-91. Review. No abstract available. [ Abstract ]

Czajkowski C, Gibbs TT, Farb DH. (1990) Transmembrane topology of the gamma-aminobutyric acidA/benzodiazepine receptor: subcellular distribution and allosteric coupling determined in situ. Mol Pharmacol. 1989 Jan;35(1):75-84. [ Abstract ]

Publication Search via PubMed

Contact

Office: L-606
Phone: 617-638-5325; Fax: 617-638-4329
Lab Phone: 617-638-5323
Email: tgibbs@bu.edu
Ph.D.: Harvard Medical School
Laboratory Page: Laboratory of Molecular Neurobiology