JAMES A. HAMILTON, Ph.D.
JAMES A. HAMILTON, Ph.D.
Professor of Physiology and Biophysics
Research Professor of Medicine
Department of Physiology and Biophysics
Office: W302
Phone: (617) 638-5048 Fax: (617) 638-4041
Electronic mail: jhamilt@bu.edu
Ph.D.: Indiana University
Laboratory Page: http://biophysics.bumc.bu.edu/faculty/hamilton/index.html
Research Interests:
Dr. Hamilton’s laboratory is interested in developing novel physical approaches to address physiologically important issues that need further study and new insights. Both intact biological systems and simplified models thereof are examined by NMR spectroscopy and a variety of complementary techniques. For example, 13C NMR methods pioneered in this laboratory described the interactions of fatty acids in binding sites on albumin. Many of the important details predicted by NMR have been validated in the recent x-ray crystal structure. Dr. Hamilton’s laboratory has determined the complete solution structure of three intracellular fatty acid binding proteins (FABP). They are also studying binding of ligands to FABP and the molecular motions of the protein in the presence and absence of ligand. New fluorescence approaches developed in the laboratory have been used to monitor the diffusion of fatty acids into cells by measurement of intracellular pH. They are quantifying the extent and rate of fatty acid uptake into adipocytes under conditions modeling diabetes and obesity.
They are evaluating the effects of drugs and inhibitors on each aspect of fatty acid uptake with new, precise, and quantitative fluorescence measurements. Dr. Hamilton’s laboratory also has a long-term interest in the pathogenesis of arteriosclerosis, and will use magic angle spinning and solid-state techniques as newer NMR methods to decipher structural features of atherosclerotic plaques. The NMR data will be correlated with magnetic resonance images of plaques (in vivo and ex vivo) to provide a more detailed and rigorous analysis of images.
Selected Publications:
1. Schettler, P.D., C.L. Van Antwerp, J.A. Hamilton, J.E. Thilly and J.D. Spear. “Impedence Behavior of Metal-Ammonia Solid Metal Interface” (1973) in Electrons in Fluids J. Jortner and N.R. Kestner, Eds., Springer-Verlag, Berlin, p. 239.
2. Hamilton, J.A., C. Talkowski, E. Williams, E.M. Avila, A. Allerhand, E. Cordes and G. Camejo. Natural Abundance Carbon-13 Nuclear Magnetic Resonance Spectra of Human Serum Lipoproteins. (1973) Science 180:193-195.
3. Williams, E., J.A. Hamilton, M.K. Jain, A. Allerhand, E.H. Cordes and S. Ochs. Natural Abundance Carbon-13 Nuclear Magnetic Resonance Spectra of the Canine Sciatic Nerve. (1973) Science 181:869-871.
4. Rodulfo, T., J.A. Hamilton and E.H. Cordes. Secondary Valence Force Catalysis. IV. Polysoap Catalysis for the Alkaline Hydrolysis of p-Nitrophenyl Hexanoate” (1974) J. Org. Chem. 31:2281-2284.
5. Hamilton, J.A., C. Talkowski, R.F. Childers, E. Williams, A. Allerhand and E.H. Cordes. Rotational and Segmental Motions in the Lipids of Human Plasma Lipoproteins. (1974) J. Biol. Chem. 249:4872-4878.
6. Hamilton, J.A., N. Oppenheimer, R. Addleman, A. Clouse, E.H. Cordes and C.J. Glueck. High-field C-13 NMR Studies of b-VLDL of Type III Hyperlipoproteinemia Patients and of Normal Lipoproteins. (1976) Science 194:1424-1427.
7. Hamilton, J.A., N. Oppenheimer and E.H. Cordes. Carbon-13 NMR Studies of Cholesteryl Esters and Cholesteryl Ester/Triglyceride Mixtures. (1977) J. Biol. Chem. 252:8071.
8. Avila, E.M., J.A. Hamilton, C. Talkowski, J.A.K. Harmony, A. Allerhand, E.H. Cordes and G. Camejo. Structure of Plasma Lipoproteins. (1977) Act. Cient. V. 28: 37-43.
9. Avila, E., J.A. Hamilton, J. Harmony, A. Allerhand and E.H. Cordes. Natural Abundance 13C Nuclear Magnetic Resonance Studies of Human Plasma High Density Lipoproteins. (1978) J. Biol. Chem. 253:3983-3987.
10. Hamilton, J.A. and E.H. Cordes. Molecular Dynamics of Lipids in Human Plasma High-Density Lipoproteins: A High-field 13C NMR Study. (1978) J. Biol. Chem. 253:5193-5198.
11. Hamilton, J.A., E.H. Cordes and C.J. Glueck. Lipid Dynamics in Human Low-Density Lipoproteins and Human Aortic Tissue with Fibrous Plaques: A Study by High-Field 13C NMR. (1979) J. Biol. Chem. 254:5435-5441.
12. Brainard, J.R., J.A. Hamilton, E.H. Cordes, J.R. Patsch, A.M. Gotto and J.D Morrisett. Lipoprotein-X: 13C-NMR Studies on Native, Reconstituted and Model Systems. (1980) Biochemistry 19:4266-4273.
13. Hamilton, J.A. and D.M. Small. Solubilization and Localization of Triolein in Phosphatidylcholine Bilayers: A Carbon-13 NMR Study. (1981) Proc. Natl. Acad. Sci. USA 78:878-6882.
14. Bennett Clark, S., D. Atkinson, J.A. Hamilton, T. Forte, B. Russell, E.B. Feldman and D.M. Small. Physical Studies of d<1.006 g/ml Lymph Lipoproteins from Rats Fed Palmitate-Rich Diets. (1982) J. Lipid Res. 23:28-41.
15. Cistola, D.P., D.M. Small and J.A. Hamilton. Ionization Behavior of Aqueous Short-Chain Carboxylic Acids: A Carbon-13 NMR Study. (1982) J. Lipid Res. 23:795-799.
16. Hamilton, J.A. and D.M. Small. Solubilization and Localization of Cholesteryl Oleate in Egg Phosphatidylcholine Vesicles: A Carbon-13 NMR Study. (1982) J. Biol. Chem. 257:7318-7321.
17. Ginsburg, G.S., D.M. Small and J.A. Hamilton. Temperature-Dependent Molecular Motions of Cholesterol Esters: A Carbon-13 Nuclear Magnetic Resonance Study. (1982) Biochemistry 21:6857-6867.
18. Small, D.M., K. Miller, D. Cistola, G. Ginsburg, J. Parks, D. Atkinson and J.A. Hamilton. Physicochemical Studies on the Position of Molecules in Emulsions and Membranes. (1983) Bile Acids and Cholesterol in Health and Disease, G. Baumgartner, A. Stiehl and W. Gerok, eds., MTP Press Ltd., Boston, pp 25-30.
19. Hamilton, J.A., D.M. Small and J. Parks. 1H NMR Studies of Monkey Triglyceride-Rich Lipoproteins. (1983) J. Biol. Chem. 258:1172-1179.
20. Parks, J.S., D.P. Cistola, D.M. Small and J.A. Hamilton. Interactions of the Carboxyl Group of Oleic Acid with Bovine Serum Albumin: 13C NMR Study. (1983) J. Biol. Chem. 258:9262-9269.
21. Hamilton, J.A., K.W. Miller and D.M. Small. Solubilization of Triolein and Cholesteryl Oleate in Egg Phosphatidylcholine Vesicles. (1983) J. Biol. Chem. 258:12821-12826.
22. Hamilton, J.A., D.P. Cistola, J.D. Morrisett, J.R. Sparrow and D.M. Small. Interactions of Myristic Acid with Bovine Serum Albumin: A 13C NMR Study. (1984) Proc. Natl. Acad. Sci USA 81:3178-3722.
23. Morrisett, J.D., J.W. Gaubatz, A.P. Tower, J.K. Allen, H.J. Pownall, P. Laggner and J.A. Hamilton. Thermotropic Properties and Molecular Dynamics of Cholesteryl Ester-Rich Very Low Density Lipoproteins. (1984) Biochemistry 23:5343-5352.
24. Small, D.M., D.J. Cabral, D.P. Cistola, J.S. Parks and J.A. Hamilton. The Ionization Behavior of Fatty Acids and Bile Acids in Models and Membranes. (1984) Hepatology 4:77S-79S.
25. Croll, D.H., D.M. Small and J.A. Hamilton. Molecular Motions and Thermotropic Phase Behavior of Cholesteryl Esters with Triolein. (1985) Biochemistry 24:7971-7980.
26. Hamilton, J.A. and J.D. Morrisett. NMR Studies of Plasma Lipoproteins. (1986) Methods in Enzymology 28:472-515.
27. Hamilton, J.A. and D.P. Cistola. Transfer of Oleic Acid between Albumin and Phospholipid Vesicles. (1986) Proc. Natl. Acad. Sci. USA 83:82-86.
28. Cabral, D., D.M. Small and J.A. Hamilton. The Ionization Behavior of Bile Acids in Different Aqueous Environments. (1986) J. Lipid Res. 27:334-343.
29. Cistola, D.P., D.M. Small, D. Atkinson and J.A. Hamilton. The Phase Behavior of Anhydrous and Hydrated 1:1 Fatty Acid-Soaps. (1986) Biochemistry 25:2804-2812.
30. Croll, D., D.M. Small and J.A. Hamilton. Molecular Motions of Saturated Cholesteryl Esters. (1986) J. Chem. Phys. 85:7380-7387.
31. Spooner, P.S., J.A. Hamilton, D.L. Gantz and D.M. Small. (1986) The Effect of Free Cholesterol on Solubilization of Cholesteryl Oleate in Phosphatidylcholine Bilayers: A 13C NMR Study. (1986) Biochim. Biophys. Acta 860:345-353.
32. Cabral, D.J., D.M. Small, H.S. Lilly and J.A. Hamilton. Transbilayer Movement of Bile Acids in Model Membranes. (1987) Biochemistry 26:1801-1804.
33. Small, D.M. and J.A. Hamilton. Can NMR Detect Cancer? (1987) New Eng. J. Med. 316:1411-1412.
34. Cistola, D.P., D.M. Small and J.A. Hamilton. Carbon-13 NMR Studies of Saturated Fatty Acids Bound to Bovine Serum Albumin. I. The Filling of Individual Binding Sites. (1987) J. Biol. Chem. 262:10971-10979.
35. Cistola, D.P., D.M. Small and J.A. Hamilton. Carbon-13 NMR Studies of Saturated Fatty Acids Bound to Bovine Serum Albumin. II. Electrostatic Interactions in Individual Fatty Acid Binding Sites. (1987) J. Biol. Chem. 262:10980-10985.
36. Sripada, P.K., P.R. Maulik, J.A. Hamilton and G.G. Shipley. Partial-synthesis and Properties of a Series of N-acyl Sphingomyelins. (1987) J. Lipid Res. 28:710-718.
37. Croll, D., P.K. Sripada and J.A. Hamilton. Temperature-Dependent Molecular Motions and Phase Behavior of Cholesteryl Ester Analogues. (1987) J. Lipid Res. 28:1444-1454.
38. Cistola, D.P., M.T. Walsh, R.P. Corey, J.A. Hamilton and P. Brecher. Interactions of Oleic Acid with Liver Fatty Acid Binding Protein: A Carbon-13 NMR Study. (1988) Biochemistry 27:711-717.
39. Cistola, D.P., J.A. Hamilton, D.M. Small and D. Jackson. The Ionization and Phase Behavior of Fatty Acids in Water: Application of the Gibbs Phase Rule. (1988) Biochemistry 27:1881-1888.
40. Spooner, P.J.R., S. Bennett Clark, D.L. Gantz, J.A. Hamilton and D.M. Small. The Ionization and Distribution Behavior of Oleic Acid in Chylomicrons and Chylomicron-Like Emulsion Particles and the Influence of Serum Albumin. (1988) J. Biol. Chem. 263:1444-1453.
41. Walsh, M.T., J.A. Hamilton, D. Atkinson and D.M. Small. Secondary and Tertiary Structure of Apolipoproteins. In Eicosanoids, Apolipoproteins, Lipoprotein Particles and Atherosclerosis. (Claude Malmendier, ed.) Plenum Publishing Co., New York NY (1988) pp 123-132.
42. Hamilton, J.A. Interaction of Triglycerides with Phospholipids: Incorporation into the Bilayer Structure and Formation of Emulsions. (1989) Biochemistry 28:2514-2520.
43. Hamilton, J.A. Medium Chain Fatty Acid Binding to Albumin and Transfer to Phospholipid Bilayers. (1989) Proc. Natl. Acad. Sci. 86:2663-2667.
44. Bhamidipati, S.P. and J.A. Hamilton. Hydrolysis of a Phospholipid in an Inert Lipid Matrix by Phospholipase A2: A 13C NMR Study. (1989) Biochemistry 28:6667-6672.
45. Deckelbaum, R.J., J.A. Hamilton, A. Moser, G. Bengtsson-Olivecrona, E. Butbul, Y. Carpentier, A. Gutman and T. Olivecrona. Medium Chain vs. Long Chain Triacylglycerol Emulsion Hydrolysis by Lipoprotein Lipase and Hepatic Lipase: Implications for the Mechanisms of Lipase Action. (1990) Biochemistry 29:1136-1142.
46. Spooner, P.S., D.L. Gantz, J.A. Hamilton, and D.M. Small. The Distribution Behavior of Oleic Acid between a Chylomicron-Like Emulsion, Phospholipid Bilayer, and Serum Albumin. (1990) J. Biol. Chem. 265:12650-12655.
47. Deshpande, M.S., J.G. Boylan and J.A. Hamilton. Inhibitors of Tissue Kallikrein, Based on the Structure of the Porcine Pancreatic Kallikrein/Aprotinin Complex. In Proceedings of the 11th American Peptide Symposium. (J. Rivier, ed.) Escom (1990).
48. Hamilton, J.A., S. Bhamidipati, D. Kodali and D.M. Small. The Interfacial Conformation and Transbilayer Movement of Diacylglycerols in Phospholipid Bilayers. (1991) J. Biol. Chem. 266:1177-1186.
49. Hamilton, J.A., S. Era, S.P. Bhamidipati and R.A. Reed. Oleic Acid Binding to Bovine Serum Albumin Fragments and Reassembled Albumin. (1991) Proc. Natl. Acad. Sci. USA 88:2051-2054.
50. Hamilton, J.A., D.T. Fujito and C.F. Hammer. Solubilization and Localization of Weakly Polar Lipids in Unsonicated Egg Phosphatidylcholine: A 13C MAS-NMR Study. (1991) Biochemistry 30:2894-2902.
51. Deshpande, M.S., J. Boylan, J.A. Hamilton and J. Burton. Conformation and Inhibitory Properties of Peptides Based on the Tissue Kallikrein-Aprotinin Complex. (1991) Internat. J. Peptides 37:536-543.
52. Bhaskar, K.R., D. Gong, R. Bansil, S. Pajevic, J.A. Hamilton, B.S. Turner and J.T. LaMont. Profound Increase in Viscosity and Aggregation of Pig Gastric Mucin at Low pH. (1991) Gastroentereology 6827-6832.
53. Boylan, J.G. and J.A. Hamilton. Interactions of acyl Coenzyme A with Phosphatidylcholine Bilayers and Serum Albumin. (1992) Biochemistry 31:557-567.
54. Hamilton, J.A. Binding of Fatty Acids to Serum Albumin: A Case Study of Lipid-Protein Interactions. (1992) News in Physiological Sciences 7:264-270.
55. Kamp, F. and J.A. Hamilton. pH Gradients Caused by Fast Flip-Flop of Un-ionized Fatty Acids in Phospholipid Bilayers. (1992) Proc. Natl. Acad. Sci. USA 89:11367-11370.
56. Smith, Steven O., I. Kustanovich, S. Bhamidipati, A. Salmon and J.A. Hamilton. Interfacial Conformation of Dipalmitoylglycerol and Dipalmitoylphosphatidylcholine in Phospholipid Bilayers. (1992) Biochemistry 31:11660-11664.
57. Bhamidipati, S.B. and J.A. Hamilton. NMR Studies of Phospholipase C Hydrolysis of Phosphatidylcholine in Model Membranes. (1993) J. Biol. Chem. 268:2431-2434.
58. Guo, W. and J.A. Hamilton. Molecular Organization and Motions of Cholesteryl Esters in Crystalline and Liquid Crystalline Phases: A 13C and 1H Magic Angle Spinning NMR Study. (1993) Biochemistry, 32:9038-9052.
59. Kamp, F. and J.A. Hamilton. Movement of Fatty Acids, Fatty Acid Analogues and Bile Acids Across Phospholipid Bilayer. (1993) Biochemistry 32:11074-11086.
60. Petrou, S., R.W. Ordway, J.A. Hamilton, J.V. Walsh, Jr. and J.J. Singer. Structural Requirements for Charged Lipid Molecules to Directly Increase or Suppress K+ Channel Activity in Smooth Muscle Cells. (1994) J. Gen. Physiol. 104:471-486.
61. Kenyon, M. and J.A. Hamilton. 13C NMR Studies of Medium-Chain Fatty Acids Binding to Human Serum Albumin. (1994) J. Lipid Res. 84, 458-467.
62. Hamilton, J.A. Studies of Minor Lipid Constituents of Membranes by High Resolution and Solid State 13C NMR Spectroscopy: Interactions with Phospholipid Bilayers and Transport Proteins. (1995) Chapter 4 In “Carbon-13 Magnetic Resonance Spectroscopy of Biological Systems” (N. Beckmann, ed.) Academic Press, 117-151.
63. Ko, J., J.A. Hamilton, H-T. Ton Nu, C.D. Schteingart, A.F. Hofmann, D.M. Small. The Effects of Side Chain Length on Ionization Behavior and Transbilayer Transport of Dihydroxy Bile Acids. (1994) J. Lipid Res. 35:883-892.
64. Hamilton, J.A., V.N. Civelek, F. Kamp, K. Tornheim and B.E. Corkey. Changes in Internal pH Caused by Movement of Fatty Acids Into and Out Of Clonal Pancreatic b-Cells (HIT). (1994) J. Biol. Chem. 269:20852-20856.
65. Smith, S.O., J. A. Hamilton, A. Salmon and B.J. Bormann. Rotational Resonance NMR Determination of Intra-and Intermolecular Distance Constraints in Dipalmitoylphosphatidylcholine Bilayers. (1994) Biochemistry 33:6327-6333.
66. Guo, W. and J.A. Hamilton. Molecular Organization and Motions of Crystalline Monoacylglycerols and Diacylglycerols: A C-13 MASNMR Study. (1995) Biophys J. 68:1383-1395.
67. Bhamidipati, S.P. and J.A. Hamilton. Interactions of lyso 1-palmitoyl phosphatidylcholine with phospholipids: a 13C and 31P NMR study. (1995) Biochemistry 34:5666-5677.
68. Guo, W. and J.A. Hamilton. Phase behavior and crystallization of cholesteryl ester mixtures: A C-13 MASNMR study. (1995) Biophys. J. 68, 2376-2386.
69. Petrou, S., R.W. Ordway, M.T. Kirber, A.M. Dopico, J.A. Hamilton, J.V. Walsh, Jr. and J.J. Singer. Direct effects of fatty acids and other charged lipids on ion channel activity in smooth muscle cells. (1995) Prostaglandins, Leukotrienes, and Essential Fatty Acids. 52:173-178.
70. Kamp, F., D. Zakim, N. Noy, and J.A. Hamilton. Fatty acid flip-flop in phospholipid vesicles is extremely fast. (1995) Biochemistry. 34:11928-11957.
71. Ho., J., H. Moser, Y. Kishimoto and J.A. Hamilton. Interactions of very long chain fatty acid with model membranes and serum albumin: Implications for the pathogenesis of adrenoleukodystrophy. (1995) J. Clin. Invest. 96: 1455-1463.
72. Morrisett J. and J.A. Hamilton. NMR of Lipoproteins. (1996) In Encyclopedia of NMR. 2736-2744.
73. Hamilton, J.A., J.M. Vural, Y.A. Carpentier and R.J. Deckelbaum. Incorporation of Medium chain triacylglycerols into phospholipid bilayers: effect of long chain triacylglycerols, cholesterol, and cholesteryl esters.(1996) J. Lipid Res. 37: 773-782.
74. Boyle, E., D.M. Small, D. Gantz, J.A. Hamilton, and J.B. German. Monoacylglycerols Alter the Lipid Composition and Molecular Mobility of Phosphatidylcholine Bilayers:13C NMR Evidence of Dynamic Lipid Remodeling. (1996) J. Lipid Res 37:764-772.
75. Bird, D.A., M. Laposata, and J.A. Hamilton. Binding of Ethyl Oleate to Low Density Lipoprotein, Phospholipid Vesicles and Albumin: A13C NMR Study. (1996) J. Lipid Res. 37, 1449-1458.
76. Lücke, C., F. Zhang, H. Rüterjans, J. A. Hamilton, and J.C. Sacchettini. Sequence-Specific 1H-NMR Assignment and Structure Determination of Ileal Lipid Binding Protein. (1996) Structure 4:785-800.
77. Civelek, V.N., J.A. Hamilton, K. Tornheim, K.L. Kelly and B.E. Corkey. Intracellular pH regulation in adipocytes: Effects of free fatty acids, lipolytic agents and insulin. (1996) PNAS USA 93:10139-10144.
78. Guo, W. and J.A.Hamilton, (1996) 13C MAS NMR Studies of Crystalline Cholesterol and Lipid Mixtures Modeling Atherosclerotic Plaques. Biophys. J. 71: 2857-2868.
79. Shekar, S.C. and J.A.Hamilton (1997) Separation of a Pair of Interleaved Sideband Families in Magic Angle Spinning NMR by a pair of One-dimensional Experiments. Magnetic Resonance in Chemistry 35:302-305.
80. Ek, B.A., Cistola, D.P., Hamilton, J.A., Kaduce, T.L., and A. Spector (1997) Fatty Acid Binding Proteins reduce 15-lipoxygenase-induced Deoxygenation of Linoleic and Arachidonic Acid. Biochim. Biophys. Acta 1346:
81. Zhang, F., Kamp, F., and J. A. Hamilton (1997) Dissociation of Long and Very Long Chain Fatty Acids from Phospholipid Bilayers. Biochemistry 35:16055-16060.
82. Zhang, F. Luecke, C., Baier, L.J., Sacchettini, J. C., and James A. Hamilton (1997) Solution Structure of human I- FABP: Implications for ligand entry and exit. (1997) J. Biomolecular NMR 9: 213-228.
83. Hamilton, James A. (1998) Fatty acid transport: difficult or easy? J. Lipid Res.39: 467-481.
84. Guo, W., Morrisett, J.D., Lawrie, G.M., DeBakey, M.E., and J.A. Hamilton (1998) Identification of Different Lipid Phases and Calcium Phosphate Deposits in Human Carotid Arteries by MAS NMR Spectroscopy. Magnetic Resonance in Medicine 39:184-189.
85. Guo, W., Kirkland, J.L., Corkey, B., and J.A. Hamilton (1998) A 13C NMR study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes. Lipids 33, 449-454.
86. Ek, B.A., Hamilton, J.A., and Spector A.A. (1997) Binding of Fatty Acids to FABPs reduces 15-lipoxygenase mediated Peroxidation. in Essential Fatty Acids and Eicosnaoids, ISSFAL, 182-185.
87. Lucke, C., Fushman, D., Ludwig, C., Hamilton, J.A., Sacchettini, J.C., and Ruterjans, H. (1999) Comparative study of the backbone dynamics of two closely related lipid binding proteins: bovine heart FABP and porcine ILBP. Molec. Cell Biochem.,192, 109-121.
88. Hamilton, J.A. (1999) Transport of fatty acids across membranes by the diffusion mechanism. Prostaglandins, Leuckotrienes, and Essential Fatty Acids, 60(5&6), 291-297.
89. Guo, W., Choi, J-K. Kirkland, J.L., Corkey, and Hamilton, J.A. (1999) Incorporation of 13C oleic acid into cellular triglycerides in differentiating 3T3L1 cells. Lipids 34, 825-831.
90. Guo, W., Kirkland, J.L., Corkey, and Hamilton, J.A. (1999) Storage of free fatty acids in preadipocytes: a comparison between octanoate and oleate, submitted.
91 Hamilton J.A. and Kamp, F. (1999) How are free fatty acids transported in membranes: by protein transport or by free diffusion?, Diabetes, 48, 2255-2269.
92 Guo, Wen, Kirkland, J., Choi, J-K., Corkey, B.E. and Hamilton, J.A. (2000) “Storage of Free Fatty Acids in Preadipocytes: A Comparison between Octanoate and Oleate”. Biochem. J. 349, 463-471.
93 Lücke, C., Zhang, F., Hamilton, J.A., Sacchettini, J.C., and Rüterjans, H. (2000) Solution Structure of Ileal Lipid binding Protein in Complex with Glycocholate. Eur. J. Biochem. 267, 2929-2938.
94 Civelek, Vildan N., G.C.Yaney, AM Richard, J.S Dillon, J.T. Deeney, J.A. Hamilton, H.M. Korchak, K. Tornheim, B.E. Corkey and A.E. Boyd, III. (1999) Glucagon-like Peptide-1 Stimulates Lipolysis in Clonal Pancreatic ß-Cells (HIT). Diabetes, in press.
95 Caserta, Frank, V.N. Civelek, S. Thumelin, M. Prentki, N.F. Borwn, J.D. McGarry, T. Tchkonia, A.R. Forse,. B.E. Corkey, J.A. Hamilton, and J.L. Kirkland. (2000). Fat Depot Origin Affects Fatty Acid Handling in Cultured Rat and Human Preadipocytes. Am .J. Physiol Endocrinol. Metab. 280: E238-E247.
96 Peng, Shaoquing, Guo, W., Morrisett, J.D., Michael T. Johnstone and Hamilton, J.A. (2000) Quantification of Cholesteryl Esters in Human and Animal Atherosclerotic Plaques by Magic Angle Spinning 13C NMR. Arteriosclerosis, Thrombosis and Vascular Biology, in press.
97 Guo, Wen, Morrisett, J., DeBakey, M.E., Lawrie, G.M. and Hamilton, J.A. Quantitation in situ of crystalline cholesterol and calcium phosphate hydroxapatite in human atherosclerotic plaques by solid state magic angle spinning NMR. (2000). Arteriosclerosis, Thrombosis and Vascular Biology. 20: 1630-1636.
98 J.A. Hamilton, R. A. Johnson, B.E. Corkey, F. Kamp (2001) Fatty Acid Transport: the diffusion mechanism in model membranes, J. Molec. Neurosciences, 16: 13-22.
99 Michael T. Johnstone, R. Botnar, A.S. Perez, R. Stewart, W. Quist, J.A. Hamilton and W.J. Manning. 2001. In Vivo Magnetic Resonance Imaging of New Thrombus Formation Arteriosclerosis, Thrombosis and Vascular Biology, 20;2682-2688.
100 Gordon C. Yaney, V.N. Civelek, A-M Richard, J.S. Dillon, J.T. Deeney, J.A.Hamilton, H.M. Korchak, K.Tornheim, B.E. Corkey and A.E. Boyd, III. 2001. Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic b-Cells (HIT) Diabetes. 50: 56-62.
101 Frank Caserta, T. Tchkonia, V.N. Civelek, M.Prentki, N.F. Brown, J.D. McGarry, R.A.Forse, B.E. Corkey, J.A.Hamilton and J.L. Kirkland. 2001 Fat Depot Origin Affects Fatty Acid Handling in Cultured Rat and Human Preadipocytes. Am .J. Physiol Endocrinol. Metab. 280: E238-E247.
102 Bengt A. Ek-von Mentzert, F. Zhang and J.A. Hamilton. 2001 Binding of 13-HODE and 15-HETE to phospholipid bilayers, albumin and intracellular fatty acid binding proteins. The Journal of Biological Chemistry. 276: 15575-15580.
103 Groesbeek, M., W. Guo, S.O. Smith and J.A. Hamilton. 2001. NMR Spectroscopy of Dimyristoylphosphatidylcholine. Influence of Temperature and Magic Angle Spinning of Hydration. Biophysical Journal. Submitted.
104 Wen, Guo, V. Kurze, T. Huber, A.H. Nezam, K. Beyer and J.A. Hamilton. 2001. A multinuclear solid-state NMR study of sphingomyelin-cholesterol interactions. Submitted to Biophysical Journal.
105 Ho, J. Duclos, R., and Hamilton, J.A. 2001 Interactions of acyl carnitines with model membranes: A13 nuclear magnetic resonance study. Submitted to Biochemistry.
106 Ji-Kyung Choi, Ho, J.K., Donghui, Q., Bittman, R., and Hamilton, J.A. 2001. Interactions of Very Long Chain Fatty Acids with Bovine Serum Albumin Submitted to Biochemistry.
