DOUGLAS L. ROSENE, Ph.D.
DOUGLAS L. ROSENE, Ph.D.
Associate Professor of Anatomy and Neurobiology
Department of Anatomy and Neurobiology
Office: CABR W-701A (Center for Advanced Biological Research)
Phone: (617) 638-4061
Fax: (617) 638-4922
Electronic Mail: drosene@cajal-1.bu.edu
Ph.D.: University of Rochester Laboratory
Web Site: Laboratory Cognitive Neurobiology
Research Interests:
Dr. Rosene’s research interests center on identifying the neurobiological basis of normal learning and memory and related cognitive functions in the normal brain and the disruption of these processes in various neurodegenerative diseases, specific and localized forms of neurological damage and other stress such a malnutrition. To accomplish this, multidisciplinary studies of animal models use combinations of behavioral, neurohistochemical, neurophysiological and neuroanatomical techniques to study these cognitive functions. They use the rhesus monkey as a non-human primate model of normal aging and of cerebrovascular disease and other neurological disorders as well as a rat model of prenatal malnutrition. Specific methods used include MRI and PET scans, standard histology, quantitative neuroanatomy using modern stereological methods, immunocytochemistry, enzyme histochemistry, on the slide receptor autoradiography, in situ hybridization, in vivo neurophysiology, and a variety of cognitive and behavioral testing methods.
Selected Publications:
Rosene, D.L. and Nicholson, T.J. Some Neurotransmitter receptor changes in the hippocampus and cerebral cortex in normal aging. In: Cerebral Cortex, Neurodegenerative and Age-related Changes in Cerebral Cortex. Vol 14. Jones, E.G., Peters, A. and Morrison, J.H. (Eds), Kluwer Academic/Plenum Publishers, N.Y, pp. 111-128, 1999.
E. Bartolak-Suki, J.D. Sipe, R.E. Fine, D.L. Rosene, and M.B. Moss. Serum AmyloidA is present in the capillaries and microinfarcts of hypertensive monkey brain: an immunohistochemical study. Amyloid: Int. J. Exp. Clin. Invest. 7:111-117, 2000.
Sloane JA, Hollander W, Rosene DL, Moss MB, Kemper T, Abraham CR, strocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey. Brain Res 862: 1-10, 2000.
