Dr. Zhen Jiang’s New C2 Domain Discovery in April Molecular and Cell Biology’s “Selected as Article of Significant Interest . . . by the Editors”

in Faculty Spotlight
April 5th, 2018

Zhen Y. Jiang, M.D., Ph.D., and his research group, have discovered a new C2 domain containing phosphoprotein CDP138 that is important for membrane trafficking. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release in the April 2018 edition of Molecular and Cellular Biology and featured in Articles of Significant Interest Selected from This Issue by the Editors. Dr. Zhen and his group generated the first CDP138 knockout mice and revealed that CDP138 deficient mice are prone to develop obesity and insulin resistance. They discovered that CDP138 is a factor involved in the regulation of fat browning, energy metabolism, and insulin sensitivity through controlling sympathetic nervous function and the transmission of adrenergic signals. Per the editors’ comment, “These findings provide the first evidence that CDP138 affects energy balance and insulin sensitivity through the transmission of adrenergic signals.”

Dr. Jiang, is Associate Professor of Pharmacology and Medicine, Division of Endocrinology, Diabetes, and Nutrition, at Boston University School of Medicine, and a member of the Whitaker Cardiovascular Institute at Boston University. He is the Director of the Laboratory of Diabetes and Obesity Research.

Congratulations to Dr. Jiang and his group on this important discovery.