Departmental Seminar – Friday October 23
October 23 – Friday @ 2:00
“Role of SHP2 in Development and Disease: from Congenital Heart Disease to Lupus”
Maria Kontaridis, PhD
Assistant Professor of Medicine
Cardiovascular Research Cardiovascular Division
Best Israel Deaconess Medical Center; Harvard Medical School
Refreshments at 1:45 p.m.
670 Albany Street – Lobby Level #107/108
Contact:
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).
At the conclusion of this activity participants will be able to: 1) state that congenital heart disease (CHD) is the most common birth defect worldwide; however, underlying mechanisms remain unknown; 2) recognize that the loss-of-function mutations in PTPN11, the gene encoding the protein tyrosine phosphatase SHP2, are implicated in CHD and cause Noonan Syndrome with Multiple Lentigines (NSML) and 3) report that NSML presents with multiple cardiac defects, the most prevalent of which is hypertrophy.