March 2014

Pathology & Laboratory Medicine News Items

 Announcements:

          • Nader Rahimi, PhD had recent work in the news and this work was described as a future medicine for cancer treatment (please see link) Rahimi2014.future medicine
          • Huihong Xu, MD was invited to give a lecture of “Frozen Section Diagnosis” at China Shanghai Fudan University Cancer Hospital, Department of Pathology, on January 8th
          • John “Jed” Mahoney , PhD, Cardoso Lab, successfully defended his thesis “The Hippo Pathways Effector Yap Controls Patterning and Differentiation of the Airway Epithelium” on Friday, March 21st   
          • Evan Chiswick , PhD, Remick Lab, successfully defended his thesis “Failure to Kill, Kills: Impaired Bacterial Killing Precedes Death in Polymicrobial Sepsis” on Friday, March 28th   
          • Shinichiro Kurosawa, MD, PhD was invited to give a seminar on March 10th at Harvard Medical School at a joint symposium of the BWH-DFCI Joint Immunology Seminar Series.  The title of his talk was “A pre-clinical animal model of B. anthracis infection:  A new insight into the cause of death.”
          • The Hematology Lab will be providing “Immunofecal Occult Blood Testing” as of 3/17/14, which will be used in screening patients for gastrointestinal bleeding and colorectal cancer. The hematology lab will be using Polymedco’s OC-AUTO Micro 80 platform. This test is more sensitive (one specimen instead of multiple) and more specific (you can eat a hamburger beforehand) than the “Guaic Test”. Melissa Gallinaro, Daoreuang Pongvongkeo, John Lee, Chris Andry, and Carl O’Hara were involved in bringing this test in-house and validating this test.
          • The Hematology Lab will also be providing in-house “Platelet Aggregation Testing” as of 3/17/14, which will be used in assessing baseline platelet function as well as antiplatelet drug efficacy. The hematology lab will be using Chrono-log’s Model 700 Aggregometer platform. This platform uses aggregation impedence methodology, which is favored over the traditional light transmittance methology. Renee Nutting, Daoreuang Pongvongkeo, and John Lee were involved in bringing this test in-house and validating this test.
          • USCAP 2014, United States & Canadian Academy of Pathology’s 103rd  Annual Meeting;         San Diego, California; March 1 – 7, 2014:
            • PhD Candidate, Philip Bondzie, Henderson Lab presented a poster entitled:Glomerular Gene Expression Profiling and Kidney Morphology in Carriers of APOL1 Risk AllelesBondzie P, Norman T, Yang S, Henderson JM
            • Abstracts from our faculty, residents and fellow:
              • “PD-L1 Expression in Stage IV Lung Cancer”. Yue Sun, Huihui Ye, Hao Wu, and Carl O’Hara

                USCAP2014.SunYue.DSC_0479

                Dr. Yue Sun with her poster presentation

              • “Correlation of TWIST Expression in Different Histologic Subtypes of Primary Adenocarcinoma in Lung”. Anita Malek , Hasmeena Kathuria, Carl O’Hara 

                USCAP2014.AnitaMalek.DSC_0477

                Dr. Anita Malek with her poster presentation

              • “The Processing of Surgical Specimens with Forensic Evidence: Lesson’s Learned from the Boston Marathon Bombing”. Cathryn Byrne-Dugan MD, MPH; Anita Deshpande MD, Terra Ceddroth MD, Daniel Remick, MD
              • “HSATII as a Biomarker for Papillary Thyroid Carcinoma”. Anita Deshpande, M.D., Josenia Narcisa M Tan, M.D., Kshitij Arora, M.D.,Vikram Deshpande, M.D.,David Ting, M.D., Antonio de las Morenas M.D., PhD  

                Dr. Anita Despande and Dr. Joy Tan with their poster presentation

                Dr. Anita Despande and Dr. Joy Tan with their poster presentation

              • “Combined Cytology and HPV Testing after Loop Electrosurgical Excision Procedure (LEEP)/Conization of the Cervix Increases the Rate of Detection of Residual Cervical Intraepithelial Neoplasia in Patients with Negative Margins”. Josenia N.M. Tan M.D., Dhay Kamel M.D., Huihong Xu M.D
              • “Papillary Thyroid Carcinoma and Chronic Lymphocytic Thyroiditis, Linked by Severity of Chronic Inflammation or Anti-Thyroid Autoantibodies?” Josenia N.M. Tan M.D.,  Antonio de las Morenas M.D., PhD  

                Dr. Joy Tan with her poster presentation

                Dr. Joy Tan with her poster presentation

            • PhD Candidate, Mostafa Belghasem’s, Henderson Lab poster was: “Molecular Profiling of Glomeruli in a Glomerular Hypertension Mouse Model” Authors: Mostafa Belghasem, MD, Philip Bondzie, Timothy Norman, Meizhen Cao, Hui Chen, MD, Joel Henderson, MD, PhD.
          • From the Lawreen Connors Lab:
            • PhD candidates, Clarissa Koch and Jacquelyn Sikora as well as a recent grad and new post-doc Michael Greene, PhD have all received Travel Awards from the Amyloidosis Foundation to attend and present at the IXth International Symposium on Amyloidosis. The meeting will be held in Indianapolis from April 27 – May 1
              • Clarissa will be presenting a poster entitles: “Serum and tissue levels of retinol binding protein in patients with TTR-associated forms of amyloidosis”
              • Jacquelyn’s poster presentation will be: “Non-coding genetic variation of the transthyretin gene in senile systemic amyloidosis” on April 30th
            • Dr. Connors will also be attending the meeting and presenting results of “A five year prospective longitudinal study of patients with senile systemic amyloidosis
          • Dr. Daniel Remick has recently been elected to:
            • American Society of Investigative Pathology – elected member of council 2014 – 2017
            • Association of Pathology Chairs — elected Chair of Research Committee 2014 – 2017
          • Dr. Nancy Miller presented at the University of Colorado School of Medicine Office of Continuing Education, “Point-of-Care Meets Microbiology: What We Have, What We Need, What is On the Way? Preparing for the Next Frontier at Point-of-Care” on Friday, March 28th
          • Dr. Barb Nikolajczyk had several invited presentations for March 2014:
            • Loma Linda University, Loma Linda, CA, “B cells support a dominant Th17 cytokine signature in human type 2 diabetes”
            • National Center for Advancing Translational Sciences/NIH, Rockville, MD, “B cells support a dominant Th17 cytokine signature in human type 2 diabetes”
            • American Association of Dental Researchers Annual Meeting, Charlotte, NC, “B cells link periodontal disease and type 2 diabetes”
          • Publications: PUBLISHED:

            • Zhu M1, Nikolajczyk BS; “Immune Cells Link Obesity-associated Type 2 Diabetes and Periodontitis.” Journal of  Dent Res. 2014 Apr;93(4):346-52. doi: 10.1177/0022034513518943. Epub 2014 Jan 6.
            • A 2013 paper in the Proceedings of the National Academy of Sciences raised questions about the value of using mouse models to study human disease. A group of investigators prepared a scientific rebuttal which has just been published: M. F. Osuchowski, D. G. Remick, J. A. Lederer, C. H. Lang, A. O. Aasen, M. Aibiki, L. C. Azevedo, S. Bahrami, M. Boros, R. Cooney, S. Cuzzocrea, Y. Jiang, W. G. Junger, H. Hirasawa, R. S. Hotchkiss, X. A. Li, P. Radermacher, H. Redl, R. Salomao, A. Soebandrio, C. Thiemermann, J. L. Vincent, P. Ward, Y. M. Yao, H. P. Yu, B. Zingarelli and I. H. Chaudry: “Abandon the Mouse Research Ship? Not Just Yet!” Shock, 2014
            • Fulciniti, Mariateresa, Nicola Amodio, Rajya Lakshmi Bandi, Mansa Munshi, Guang Yang, Lian Xu, Zachary Hunter, et al. “MYD88-Independent Growth and Survival Effects of Sp1 Transactivation in Waldenstrom’s Macroglobulinemia.” Blood (March 12, 2014). doi:10.1182/blood-2014-01-550509

            A Day on Capitol Hill:

            FASEB invited a representative from Pathology to attend the annual Capital Hill Day. I participated in the event representing multiple groups. Specifically, as the Chair of the Research Committee of the Association of Pathology Chairs and the Chair of the Public Affairs Working Group of the American Society of Investigative Pathology. My report that I filed with the University is shown below. – Dan Remick, March 7, 2014.

            Advocating For Increased Federal Funding For Basic Science Research

            Every year the Federation of American Societies of Experimental Biologists (FASEB) brings scientists to Washington DC as part of Capital Hill Day. Scientists from across the country meet with Congressional staff to discuss the importance of federal research funding. On March 5, 2014 scientists from 21 states met with their representatives. FASEB’s specific recommendations for funding included $32 billion for the National Institutes of Health and $7.6 billion for the National Science Foundation. The $32 billion recommendation for NIH funding represents fewer actual dollars (not inflation adjusted dollars) compared to 2010. More information about federal funding for basic science research is available on the FASEB website:  http://www.faseb.org/Policy-and-Government-Affairs/Advocacy-on-Capitol-Hill.aspx

            Three scientists from Boston University formed the State of Massachusetts delegation for Capital Hill Day. Shoumita Dasgupta,  Ph.D, from the Department of Medicine,

            Joe, Shoumita, Doug and Dan advocating for science

            Joe, Shoumita, Doug and Dan advocating for science

            Biomedical Genetics Section, Daniel Remick, M.D., from the Department of Pathology and Laboratory Medicine, and Douglas Rosene, Ph.D., from the Department of Anatomy and Neurobiology. They were escorted by Joseph Joseph McInerney, the Executive Vice President of the American Society of  of of Human Genetics. The group visited the offices of Senators Warren and Markey as well as Representatives Tierney and Kennedy.

            At each office the group gave specific information about how reduced funding for science was having multiple negative impacts. Individual stories were told including:

            • Scientists no longer doing research because of lack of funding
            • Increased scientific publications from other countries in the Journal of Immunology compared to publications from the United States
            • International genomic sequencing initiatives (e.g. Beijing Genomics Institute) surpassing efforts at the NIH.
            • Loss of funding for the Framingham Heart studies and missing a generation of data
            • Decreased funding resulting in fewer experiments to examine the devastating effects of aging. These studies require a long term, consistent commitment since aging takes place over decades and it is difficult to start and stop science.

            All of the staff assured us that the Senators and Representatives were highly supportive of increased funding for basic science research. Each agreed to submit programmatic requests to the budget committees. This will ensure that funding for basic science will be considered as an integral part of the budget process and not as a separate earmark. They also agreed to sign a “Dear Colleague” letter to be circulated to other Senators and Representatives advocating increased funding for NIH research.  On behalf of Provost Antman, the Boston University faculty invited our Senators, Representatives and their staff to come and visit the basic science labs at Boston University, and thanked them for their continued support.