December 2013

Pathology & Laboratory Medicine News Items -

Announcements:

  • Antonio de las Morenas, M.D., Professor of Pathology and Laboratory Medicine has been recognized by Boston magazine as a Top Doc in Boston. According to BU Today, “To be included in Boston magazine’s Top Doc list, physicians undergo a rigorous screening process by national medical research firm Castle Connolly. The firm gathers nominations online from other licensed physicians, conducts phone interviews with medical professionals to corroborate nominations, and checks the professional qualifications of all nominees . . .”

The list of pathologists in Boston in the top docs may be found here: http://www.bostonmagazine.com/specialty/pathology/

○      From Dr. Daniel Remick, Department Chair: the Department of Pathology and Laboratory Medicine is pleased to announce that Susan Winandy, Ph.D., will become the Director of Graduate Studies in January, 2014. Dr. Winandy is the Nancy Bucher Assistant Professor of Pathology and Laboratory Medicine. She is a member of the Immunology Training Program at Boston University and her work focuses on the study of the protein Ikaros in T cell development and function. The Department thanks Nader Rahimi, Ph.D. for his efforts over the years to the mentoring and growth of our graduate students.

  • Dr. Ivana Delalle will be directing a new graduate course, GMS PA-910 “Human Biospecimens for Research”  approved by Academic Policy Committee in November
  • Also Dr. Ivana Delalle presented a poster entitled “Differential expression of exosomal miR-29c and miR-149 in brain tissue of bipolar disorder patients and rat model of depression” by Zhan Y1, Kozubek J1, Kao P1, Rezvani A2, and Delalle I1, 1Boston Univ. Sch. Of Med., BOSTON, MA, 2Duke University, DURHAM, NC, at the Society for Neuroscience Meeting in San Diego, California on November 11, 2013
  • Nancy S. Miller, M.D. directed the “Molecular Micro Grand Slam!” sponsored by the Northeast Branch – American Society for Microbiology, December 6th, at Bristol Community College, Fall River, MA. The all-day seminar featured lectures in molecular theory & laboratory applications, and a hands-on practical workshop emphasizing good molecular techniques. Workshop faculty also included Beverley Orr, MT(ASCP) and Valerie Kosick, M(ASCP)CM from the BMC Clinical Microbiology Laboratory, and Marisa Chattman M.S., SM (ASCP)CM from Tufts Medical Center
  • Dr. Ivana Delalle was an invited lecturer at Goettingen University Medical Center, Germany (invitation by Dr. Andre Fischer, Professor at European Neuroscience Institute) on December 19; “Human biospecimens data sharing in NIH-  funded international collaborative projects”
  • PhD Candidate, Zach Hunter presented the following posters at the American Society of Hematology Annual Meeting, December 7-10; New Orleans, Louisiana:
    • “Highly Recurrent Copy Number Alterations and Insight Into The Origins Of 6q Deletions In Waldenström’s Macroglobulinemia Revealed By Whole Genome Sequencing;” Zachary Hunter, Lian Xu, Guang Yang, Xia Liu, Yang Cao, Robert Manning, Christina K Tripsas, Christopher Patterson and Steven Peter Treon
    • “Somatic Activating Mutations In CXCR4 Are Common In Patients With Waldenstrom’s Macroglobulinemia, and Their Expression In WM Cells Promotes Resistance To Ibrutinib;” Yang Cao, Zachary Hunter, Xia Liu, Lian Xu, Guang Yang, Christina K Tripsas, Robert Manning, Christopher Patterson and Steven Peter Treon
    • “Telomerase Contributes To Repair Of DNA Breaks In Myeloma Cells By Incorporating “TTAGGG” Sequences Within Genome: Biological and Translational Significance;” Jagannath Pal, Jie Ding, Subodh Kumar, Zachary Hunter, Teresa Calimeri, Jianhong Lin, Maria Gkotzamanidou, Giovanni Parmigiani, Steven Treon, Masood Shammas, and Nikhil Munshi
    • “Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström’s Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance;” Lian Xu, Zachary Hunter, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert Manning, Christopher Patterson, Christina K Tripsas, Sandra Kanan, Jiaji G Chen, Neil I Lindeman, and Steven Peter Treon
  • Barbara Nikolajczyk, PhD became an Editor of a new multi-disciplinary journal entitled “Discoveries”

Publications: ACCEPTED:

  • Zachary R. Hunter , Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert J Manning, Christina K Tripsas, Christopher J Patterson, Patricia Sheehy, and Steven P Treon; MYD88, WHIM-like CXCR4, and Somatic Deletions Associated with B-cell Lymphomagenesis Characterize the Genomic Landscape of Waldenstöm’s Macroglobulinemia. BLOOD
  • Zhu, M and Nikolajczyk, BS.  2014.  Immune cells define the inter-relationship between obesity and periodontitis Journal of Dental Research (In Press)
  • Raval, F, and Nikolajczyk, BS. 2014. The Bidirectional Relationship between Metabolism and Immune Responses. Discoveries (In press)
  • Zhu, M and Nikolajczyk, BS.  2014. Immune cells link obesity-associated type 2 diabetes and periodontitis. Journal of Dental Research (In press).

Publications: PUBLISHED:

  • Anna Eisenstein, Lev Vaisman, MASc, Hillary Johnston-Cox, Alexander Gallan, MD, Kitt Shaffer, MD, PhD, Deborah Vaughan, PhD, Carl O’Hara, MD, and Lija Joseph, MDIntegration of Basic Science and Clinical Medicine: The Innovative Approach of the Cadaver Biopsy Project at the Boston University School of MedicineThe cadaver biopsy project at Boston University School of Medicine links students’ first basic science experiences in gross anatomy with other basic science courses and later clinical course. The paper on cadaver project is in ePub version (innovation report), and will be in print in the January issue of Academic Medicine
  • Craciun FL, Iskander KN, Chiswick EL, Stepien DM, Henderson JM, Remick DG: “Early Murine Polymicrobial Sepsis Predominantly Causes Renal Injury,” Shock 2013, PMID: 24300829
  • Bauza G, Moitra R, Remick D: “Adenosine Receptor Antagonists Effect on Plasma Enhanced Killing,” Shock 2013, PMID: 24089004
  • King EG, Bauza GJ, Mella JR, Remick DG: “Pathophysiologic mechanisms in septic shock,” Lab Invest 2013, PMID: 24061288
  • Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG: “Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding,” Physiol Rev 2013, 93:1247-1288, PMID: 23899564
  • Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP: “Roles of STAT3 in protein secretion pathways during the acute-phase response,” Infect Immun 2013, 81:1644-1653, PMID: 23460517