November 2013

Pathology & Laboratory Medicine News Items –



  • Bravo! Bravo! Once again our very own, Dr. Antonio de las Morenas, has made Boston Magazine’s “Top Doctors”List for 2013. Congratulations Dr. de las Morenas!!!
  • Recent PhD graduate, Patricia Kao, now a postdoc at UC Davis, Sacramento, CA,  presented a poster with the current data from the Delalle Lab at the Society of Neuroscience Meeting in San Diego, California on November 11th, 2013; Zhan Y*, Kozubek J*, Kao P*, Rezvani A#, Delalle I*:  Differential expression of exosomal miR-29c and miR-149 in brain tissue of bipolar disorder patients and rat model of depression
  • Jason Sutin, PhD Candidate and his PI Dr. Franceshini from MGH presented a poster at the Society for Neuroscience in San Diego, California on Sunday, Nov 10, 2013. Diffuse optical spectroscopy measurements of cerebral hemodynamic and oxygen metabolism during spontaneous neuronal activity in anesthetized rats. J. Sutin, C. Chang, D. Boas, E. Brown, and M. A. Franceschini 
  • CP Resident, Dr, Dana Semmel represented BMC’s Department of Pathology at the recent 7th Annual Careers in Medicine Fair held in September
  • Dr. Barbara Nikolajczyk has been invited to present at two upcoming events:
    • Vanderbilt Diabetes Center, Vanderbilt University, Nashville, TN, “B cells regulate the dominant Th17 axis in human type 2 diabetes, 2013”
    • University of Massachusetts, Department of Biology, Lowell, MA. “Type 2 diabetes as an inflammatory disease, 2013”
  • Graduate, Edward Hartsough, PhD Methylation Paper is featured in the Science Daily News; (UPDATED LINK)

Publications: ACCEPTED:

  • Anna Belkina, Wanda Blanton, Barbara S. Nikolajczyk and Gerald V. Denis. “The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.” Accepted to Journal of Leukocyte Biology
  • Edward J Hartsough, Rosana D Meyer, Vipul Chitalia, Yan Jiang, Victor E. Marquez, Irina V. Zhdanova, Janice Weinberg, Catherine E Costello and Nader Rahimi. “Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis” Science Signaling, Dec. 2013. This paper describes a major breakthrough in the filed of signal transduction. Prior to publication of this work, it was thought that protein phosphorylation is the only mechanism controls activation of receptor tyrosine kinases (RTKs). The work by Edward Hartsough et al., for the first time demonstrates that protein methylation primes RTKs for phosphorylation and subsequent activation which leads to biological responses such as tumor angiogenesis

Publications: PUBLISHED: 

  • Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A: “Insulin growth factor binding protein 7 is a novel target to treat dementia” Neurobiol Dis 2013 Sep 25;62C:135-143. doi 10.1016/j.nbd.2013.09.011. PMID: 24075854.
  • Boyd JD, Lee-Armandt JP, Feiler MS, Zauur N, Liu M, Kraemer B, Concannon JB, Ebata A, Wolozin B, Glicksman MA; A High-Content Screen Identifies Novel Compounds That Inhibit Stress-Induced TDP-43 Cellular Aggregation and Associated Cytotoxicity” J Biomol Screen. 2013 Sep 9
  • Amy Leung, Shirley K. Nah, Whitney Reid, Atsushi EbataClarissa M. Koch, Stefano Monti, Joseph C. Genereux, R. Luke Wiseman, Benjamin Wolozin, Lawreen H. Connors, John L. Berk, David C. Seldin, Gustavo Mostoslavsky, Darrell N. Kotton, George J. Murphy “Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis” Stem Cell Reports, 31 October 2013