Zhi-Xiong Jim Xiao
Professor of Biochemistry and Medicine
Department of Biochemistry and Department of Medicine
Boston University School of Medicine
Silvio O. Conte Building, K423
72 E. Concord Street
Boston, MA 02118
Phone: 617-638-6011
Fax: 617-638-5339
Email: jxiao@bu.edu
Education
B.S., M.S., Sichuan University, The People’s Republic of China
Ph.D., University of Massachusetts at Amherst, MA
Research Interest
Cancer biology, human genetics, apoptosis, signal transduction, tumor suppressor proteins.
My laboratory is interested in the function and regulation of tumor suppressor proteins p53 and the retinoblastoma protein (RB) in response to a variety of extracellular signals with an emphasis on breast cancer and lung cancer. We have demonstrated that genotoxic stresses induce specific p53 phosphorylation and protein conformation changes that lead to p53 activation, cell cycle checkpoint and apoptosis. Furthermore, we have identified interplay between the IGF survival signaling pathway and p53 regulatory pathway. Currently we have been working to investigate (1) genotoxic insults-mediated activation of p53 and p53 family members; (2) IGF-1/AKT signaling pathway in cell survival; (3) cell cycle regulation and function of oncoprotein MDM2; (4) role of retinoblastoma protein (RB) and E2F in lung cancer; (5) animal breast cancer model with focus on the mechanism of environmental carcinogen-induced mammary tumorigenesis, and (6) role and regulation of p53 family member p63 in human tumorigenesis.
Representative Publications
Qiu, W., Wu, J., Walsh, W. M., Zhang, Y., Chang, C-Y., Fujita, J., and Xiao, ZX. (2008)Retinoblastoma protein modulates gankyri-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene, 27:4034-4043.
Chang DLF, Qiu W, Ying H, Zhang, Y. Chen CY. and Xiao ZX. (2007) ARF promotes accumulation of > retinoblastoma protein through inhibition of MDM2. Oncogene, 26: 4627-4634.
Ying, H. and Xiao, ZX. (2006)targeting retinoblastoma protein for degradation by proteasomes (review). Cell Cycle 5:506-508.
Sdek, P., Ying, H., Chang, DL., Qiu, W., Zheng, H., Allday, MJ and Xiao,ZX. (2005) MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol. Cell, 20: 699-708.
Murray, S.A., Zheng, H., Gu, L. and Xiao, Z.-X. (2003)IGF-1 activates p21 to inhibit UV-induced cell death. Oncogene, 22: 1703-1711.
Ying, H., Chang, DL., Zheng, H., McKeon, F., and Xiao, ZX. (2005) The DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol. Cell. Biol. 25:6154-6164.
Sdek, P., Ying, H., Zheng, H., Margulis, A., Tang, X., Tian, K. and Xiao.Z.X. (2004)The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J. Biol. Chem.279: 53317-22.
Murray, S.A., Zheng, H., Gu, L. and Xiao, Z.-X. (2003)IGF-1 activates p21 to inhibit UV-induced cell death. Oncogene, 22:1703-1711.
Zheng, H., You, H., Zhou, X. Z., Murray, S.A., Uchida, T., Wulf, G., Gu, L., Tang, X., Lu, K.P. and Xiao, Z.-X. (2002) The Prolyl isomerase Pin1 is a novel regulator of p53 in genotoxic response. Advanced online publication,Oct., 2, 2002. Nature, 419: 849-853 (with News and Views 419:795-797).
Grossman, S.R., Perez, M., Joseph, M., Mansur, C., Xiao, Z.-X., Kumar, S., Howley, P.M. and Livingston, D.M. (1998) p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell, 2: 405-415.
Xiao,Z.-X. Ginsberg, D., Ewen, M. and Livingston, D. M. (1996). Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. USA. 93, 4633-4637.
Xiao, Z.-X., Chen, J., Levine, A. > J., Modjtahedi, N., Xing, J., Sellers, W.R. and Livingston, D. M. (1995). Interaction between the retinoblastoma protein and the oncoprotein MDM2.Nature, 375, 694-698.
