Wande Li
Department of Biochemistry
Boston University School of Medicine
Silvio Conte Building, Lab: K121; Office: L202
72 E. Concord Street
Boston, MA. 02118
Phone: 617-638-5485
Lab: 617-638-4823
Fax: 617-638-5339
Email: wandeli@bu.edu
Education:
Medical Doctor
Master of Science in Pathology
Research Interests:
Research in this lab focuses on investigating the regulation and function of the extracellular matrix (ECM) and cytoskeleton in human deseases. The current interest is to study the regulation by metal ion homeostasis of lysyl oxidase, a copper-dependent enzyme for the ECM crosslinking.
Representative Publications:
1. Chen, L-J, Y. Zhao, S. Gao, I-N. Chou, P. Toselli, P. Stone, and W. Li (2005). Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate. Toxicol. Sci. 83, 372-379
2. Gao, S., K. Chen, Y. Zhao, C.B. Rich, L. Chen, S.J. Li, P. Toselli, P. Stone and W. Li (2005). Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts. Toxicol. Sci. 87, 197-203
3. Zhao, Y., S. Gao, I-N. Chou, P. Toselli, P. Stone and W. Li (2006). Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts. Toxicol. Sci. 90, 478-489
4. Chou, D.K., Zhao, Y., Gao, S., Chou, I-N., Toselli, P., Stone, P. and Li, W. (2007). Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts. Toxicol Sci. 99, 267-276
5. Gao, S., Zhao, Y., Kong, L., Toselli, P., Chou, I-N., Stone, P. and Li, W. (2007). Cloning and characterization of the rat lysyl oxidase gene promoter: Identification of core promoter elements and functional nuclear factor I binding sites. J. Biol. Chem. 282, 25322-25337
