Peter Polgar
Professor of Biochemistry
Department of Biochemistry
Boston University School of Medicine
Silvio Conte Building
72 E. Concord Street
Boston, MA 02118
Phone: 617-638-4717
Fax: 617-638-5339
Email: peterp@bu.edu
Education
BA UCLA, Los Angeles, CA
PhD Boston University, Boston, MA
Research Interests
We are engaged in the study of mechanisms involved in the development of hypertension and the accompanying fibrosis in the heart and lung and the contributions of the angiotensin II, AT1, endothelin ETA and ETB, and prostanoid receptors in the process. Alterations in receptor sequences are under construction in attempt to understand and counter the negative effects and promote positive effects of these vasoactive hormones. The laboratory is also differentiating human embryonic stem cells to eventually replace some of the cells damaged during hypertension and fibrosis which are critical to normal function of these organs.
Representative Publications
Huang Z, Yu J, Toselli P, Bhawan J, Sudireddy V, Taylor L, Polgar P. Angiotensin II type 1 and Bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells. J Cell Physiol. 211:816-825, 2007.
Yu J, Lubinsky D, Tsomaia N, Huang Z, TaylorL, Mierke DM, Navarro J, Miraz, O, Polgar P : Activation of ERK, JNK, Akt and G-protein Coupled Signaling by Hybrid Angiotensin II AT1/Bradykinin B2 Receptors Expressed in HEK-293 Cells. J Cell Biochem 101:192-204, 2007.
Huang Z, Taylor L, Lui B, Yu J, Polgar P. Modulation by bradykinin of angiotensin type 1 receptor-evoked rhoA activation of connective tissue growth factor expression in human lung fibroblasts. Am J Physiology-Lung,Cell and Mol Physiol. 290:L1291-1299, 2006.
Liu B, Yu J, Taylor L, Zhou X, Polgar P. Microarray and phosphokinase screenings leading to studies on ERK and JNK regulation of connective tissue growth factor expression by angiotensin II 1a and bradykinin B2 receptors. J Cell Biochem. 97:1104-1120, 2006.
Yu J, Polgar P, Lubinsky D, Gupta M, Wang L, Mierke D, Taylor L. Coulombic and hydrophobic interactions in the first intracellular loop are vital for bradykinin B2 receptor ligand binding and consequent signal transduction. Biochemistry. 44:5295-306, 2005.
Piserchio, A., V. Zelesky, J. Yu, L. Taylor, P. Polgar, and D.F. Mierke. Bradykinin B2 receptor signaling: Structural and functional characterization of the C-terminus. Biopolymers. 80:367-73 2005
Yu J, Liu B, Eramian D, Mierke D, Taylor L and Polgar P. K317, R319 and E320 within the proximal C-terminus of the bradykinin B2 receptor form a motif important for phospholipase C and phospholipase A2 but not connective tissue growth factor related signaling. J Cell Biochem 92:547-559, 2004
Pal-Ghosh R, Yu J, Prado GN, Taylor L, Mierke DF, Polgar P. Chimeric exchanges within the bradykinin B2 receptor intracellular face with the prostaglandin EP2 receptor as the donor: importance of the second intracellular loop for cAMP synthesis Arch Biochem Biophys. 415:54-62, 2003
Prado GN, Taylor L, Zhou X, Ricupero D, Mierke DF and Polgar P Mechanisms Regulating the Expression, Self-Maintenance and Signaling-Function of the Bradykinin B2 and B1 Receptors. J Cell Phys. 193:275-386, 2002.
Yu J, Prado GN, Taylor L, Pal-Ghosh R, Polgar, P Hybrid formation between the intracellular faces of the bradykinin B2 and angiotensin II AT1 receptors and signal transduction. Int Immunopharmacol. 2:1807-1822, 2002.
Yu J, Prado GN, Schreiber B, Polgar PJ, Polgar P and Taylor L. Role of Prostaglandin E2 EP Receptors and cAMP in the Expression of Connective Tissue Growth Factor. Arch Biochem Biophys 404:302-308, 2002
Yu J, Prado GN, Taylor L, Piserchio A, Gupta A, Mierke DF, Polgar P. Global chimeric exchanges within the intracellular face of the bradykinin B2 receptor with corresponding angiotensin II type Ia receptor regions: generation of fully functional hybrids showing characteristic signaling of the AT1a receptor. J Cell Biochem 85:809-819, 2002.
Piserchio A, Prado GN, Zhang R, Taylor L, Yu J, Polgar P, Mierke DF. Structural Insight into the Role of the Second Intracellular Loop of the Bradykinin B2 Receptor in Signaling and Internalization. Biopolymers 63:239-246, 2002.
