Linda Taylor
Research Assistant Professor of Biochemistry
Department of Biochemistry
Boston University School of Medicine
Silvio Conte Building, K212
72 E. Concord Street
Boston, MA 02118
Phone: 617-638-4717
Fax: 617-638-5339
Email: taylorl@bu.edu
Education
BA Brown University, Providence, RI
PhD Boston University, Boston, MA
Research Interests
Research interests include the structure function relationships of G-protein coupled receptors, particularly the bradykinin B1 and B2, angiotensin AT1, prostanoid, and endothelin receptors. These receptors are the targets of many drugs on the market today. Using mutagenesis we have been locating specific motifs or combinations of motifs in the receptors responsible for specific signals. We have also been able to block specific signals using cell permeable peptides mimicking specific receptor motifs.
Representative Publications
Huang Z, Yu J, Toselli P, Bhawan J, Sudireddy V, Taylor L, Polgar P. Angiotensin II type 1 and Bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells. J Cell Physiol. 211:816-825, 2007.
Yu J, Lubinsky D, Tsomaia N, Huang Z, TaylorL, Mierke DM, Navarro J, Miraz, O, Polgar P : Activation of ERK, JNK, Akt and G-protein Coupled Signaling by Hybrid Angiotensin II AT1/Bradykinin B2 Receptors Expressed in HEK-293 Cells. J Cell Biochem 101:192-204, 2007.
Huang Z, Taylor L, Lui B, Yu J, Polgar P. Modulation by bradykinin of angiotensin type 1 receptor-evoked rhoA activation of connective tissue growth factor expression in human lung fibroblasts. Am J Physiology-Lung,Cell and Mol Physiol. 290:L1291-1299, 2006.
Liu B, Yu J, Taylor L, Zhou X, Polgar P (2005) Microarray and phosphokinase screenings leading to studies on ERK and JNK regulation of connective tissue growth factor expression by angiotensin II 1a and bradykinin B2 receptors. J Cell Biochem. DOI 10.1002/jcb.20709.
Yu J, Polgar P, Lubinsky D, Gupta M, Wang L, Mierke D, Taylor L.(2005) Coulombic and hydrophobic interactions in the first intracellular loop are vital for bradykinin B2 receptor ligand binding and consequent signal transduction. Biochemistry. 44:5295-306.
Piserchio, A., V. Zelesky, J. Yu, L. Taylor, P. Polgar, and D.F. Mierke (2005) Bradykinin B2 receptor signaling: Structural and functional characterization of the C-terminus. Biopolymers 80:367-73.
Yu J, Liu B, Eramian D, Mierke D, Taylor L and Polgar P. (2004) K317, R319 and E320 within the proximal C-terminus of the bradykinin B2 receptor form a motif important for phospholipase C and phospholipase A2 but not connective tissue growth factor related signaling. J Cell Biochem 92:547-559.
Pal-Ghosh R, Yu J, Prado GN, Taylor L, Mierke DF, Polgar P (2003) Chimeric exchanges within the bradykinin B2 receptor intracellular face with the prostaglandin EP2 receptor as the donor: importance of the second intracellular loop for cAMP synthesis. Arch Biochem Biophys. 415:54-62.
Prado GN, Taylor L, Zhou X, Ricupero D, Mierke DF and Polgar P (2002) Mechanisms Regulating the Expression, Self-Maintenance and Signaling-Function of the Bradykinin B2 and B1 Receptors J Cell Physiol 193:275-286.
Piserchio A, Prado GN, Zhang R, Taylor L, Yu J, Polgar P, Mierke DF (2002) Structural Insight into the Role of the Second Intracellular Loop of the Bradykinin B2 Receptor in Signaling and Internalization. Biopolymers 63:239-246.
Yu J, Prado GN, Taylor L, Pal-Ghosh R, Polgar, P (2002) Hybrid formation between the intracellular faces of the bradykinin B2 and angiotensin II AT1 receptors and signal transduction. Int Immunopharmacol. 2:1807-1822.
Yu J, Prado GN, Schreiber B, Polgar PJ, Polgar P and Taylor L. (2002) Role of Prostaglandin E2 EP Receptors and cAMP in the Expression of Connective Tissue Growth Factor. Arch Biochem Biophys 404:302-308.
