Hongjie Chen
Postdoctoral Fellow
Department of Biochemistry
Boston University School of Medicine
Silvio Conte Building, K721
72 E. Concord Street
Boston, MA 02118
Lab Phone: 617-638-5095
Fax: 617-638-5339
Email: hjchen@bu.edu
Education
Ph. D., September 1997 – July 2000
Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
Field of Research: Biochemistry and Molecular Biology
M. S., September 1991 – July 1994
Shanxi Medical University, Taiyuan, Shanxi, P. R. China
Major: Biochemistry
B. S., September 1985 – June 1989
Lanzhou University, Lanzhou, Gansu, P. R. China
Major: Biochemistry
Research Interests
The role of bone marrow and stem cell receptors in vascular function, with a focus on the role of A2b adenosine receptors.
Publications
1. Hongjie Chen, Dan Yang, Shannon H. Carroll, and Katya Ravid. (2009) Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury. (Accepted by Exp. Hematol.).
2. Donald J. McCrann, Dan Yang, Hongjie Chen, Shannon H. Carroll, and Katya Ravid. (2009) Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. Cell Cycle. 8 (6): 902-908.
3. Cindy St. Hilaire, Shannon H. Carroll, Hongjie Chen, Katya Ravid. (2008) Mechanisms of induction of adenosine receptor genes and its functional significance. J. Cell Physiol. 218 (1): 35-44.
4. Hongjie Chen, Yehoshua C. Levine, David E. Golan, Thomas Michel, and Alison J. Lin. (2008) Atrial Natriurectic Peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium, J. Biol. Chem. 283 (7): 4439-4447.
5. Hongjie Chen, Thomas Michel. (2006) Insulin signaling in vascular endothelium: a key role for heterotrimeric G proteins revealed by siRNA-mediated G1 subunit knockdown, Biochemistry 45 (26): 8023-8033.
6. Charles M. Jobin*, Hongjie Chen*, Alison J. Lin*, Patrick Yacono, Junsuke Igarashi, Thomas Michel, and David E. Golan (*These authors contributed equally to this work). (2003) Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells, Biochemistry 42 (40): 11716-11725.
7. Junsuke Igarashi, Phillip A. Erwin, Ana Paula V. Dantas, Hongjie Chen, and Thomas Michel. (2003) Vascular endothelial growth factor induces EDG-1 receptors in endothelial cells: implications for cross-talk between sphingolipid and growth factor receptors, Proc. Natl. Acad. Sci. U. S. A. 100 (19): 10664-10669.
8. Hongjie Chen, Guobao Zhang, Yuying Zhang, Yicheng Dong, and Kaiyu Yang. (2000) Functional Implications of Disulfide Bond, Cys206-Cys210, in Recombinant Prochymosin (Chymosin), Biochemistry 39 (40): 12140-12148.
9. Chongjuan Wei*, Hongjie Chen*, Yuying Zhang, and Kaiyu Yang (*Both of the authors contributed equally to this work.). (2000) Analysis of the Disulfide Bonding Pattern between Domain Sequences of Recombinant Prochymosin Solubilized from Inclusion Bodies, Journal of Protein Chemistry, 19 (4): 277-284.
