Dan Yang
Research Instructor of Biochemistry
Department of Biochemistry
Ravid Lab
Boston University School of Medicine
Silvio Conte Building, Office K725, Lab K721
72 E. Concord Street
Boston, MA 02118
Office Phone: 617-638-5095
Fax: 617-638-5339
Email: yangdan@bu.edu
Education
PhD, Sun Yat-sen Medical School of Sun Yat-sen University, China, 2002
MD, Central South University Xiang-ya Medical School, China, 1992
Research Interests
My work is focused on the physiological function of the A2b adenosine receptor (A2bAR) in the cardiovascular and immune systems, using gene targeting and pharmological strategies. I am interested in understanding how the A2bAR contributes to vascular injury, atherosclerosis, thrombosis and angiogenesis, and the potential of A2bAR based therapy in the future.
Publications
1. McCrann DJ, Yang D, Chen H, Carroll S, Ravid K. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. Cell Cycle. 2009 Mar 21; 8(6).
2. Chen H, Yang D, Carroll SH, Eltzschig HK, Ravid K. Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury. Experimental Hematology 2009 May;37(5):533-8.
3. Nguyen HG, Makitalo M, Yang D, Chinnappan D, St Hilaire C, Ravid K. Deregulated Aurora-B inducing tetraploidy promotes tumorigenesis. FASEB J. 2009 March 30 (Epub ahead of print).
4. Liu L, Brown D, McKee M, Lebrasseur NK, Yang D, Albrecht KH, Ravid K, Pilch PF. Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab 2008 Oct; 8(4): 310-317.
5. Kolachala VL, Vijay-Kumar M, Dalmasso G, Yang D, Linden J, Wang L, Gewirtz A, Ravid K, Merlin D, Sitaraman SV. A2B Adenosine Receptor Gene Deletion Attenuates Murine Colitis. Gastroenterology. 2008 Sep; 135(3):861-70. Epub 2008 May 21.
6. Grenz, A., Osswald, H., Eckle, T. Yang, D., Zhang, H., Z. V., Tran, Klingel, K., Ravid, K., and Eltzschig, H. K. (2008) The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Med. 2008 Jun 24; 5(6):e137.
7. St Hilaire C, Yang D, Schreiber BM, Ravid K. B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. J Cell Biochem 2008 Apr 15; 103(6):1962-74.
8. Hurtado PA, Vora S, Sume SS, Yang D, Hilaire CS, Guo Y, Palamakumbura AH, Schreiber BM, Ravid K, Trackman PC. Lysyl Oxidase Propeptide Inhibits Smooth Muscle Cell Signaling and Proliferation. Biochem. Biophys. Res. Commun 2008 Feb 1; 366(1):156-61.
9. Yang D., Koupenova M., McCrann D.J, Kopeikina KJ., Kagan H., Schreiber B., Ravid K. The A2b adenosine receptors protects against vascular injury. Proc Natl Acad Sci U S A 2008 Jan 15; 105(2):792-6.
10. Yang D, McCrann DJ, Nguyen H, St Hilaire C, DePinho RA, Jones MR, Ravid K. Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell. 2007 Apr; 6(2):257-60.
11. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2b adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul 3; 116(7): 1913-1923.
12. Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-κB is required for UV-induced JNK activation via induction of PKCδ. Molecular Cell 2006 Feb 21: 467-480.
13. Nguyen HG, Yu G, Makitalo M, Yang D, Xie HX, Jones MR, Ravid K. Conditional overexpression of transgenes in megakaryocytes and platelets in vivo. Blood 2005 Sep; 106(6): 1559-1564.
14. Yang D., FU X.D, LI Y.Y. et al. Role of inducible nitric oxide synthase in the vascular smooth muscle cells cycle arrest induced by 17beta-estradiol. Sheng Li Xue Bao 2003 Dec 25; 55(6): 684-691.
15. Tan Z., Wang TH, Yang D. et al. The mechanisms of 17β- estradiol on the production of ET-1 in ovariectomized rats. Life Sciences. 2003 Oct 10; 73(21):2665-74.
16. Wang TH, Fu XD, Yang D et al. Membrane estrogen receptor mediates the rapid nongenomic activation of endothelial nitric oxide synthase by estrogen. Sheng Li Xue Bao. 2003 Apr 25; 55(2):213-218.
17. Wang TH, Tan Z., Fu XD, Yang D., et al. Effect of ERK on 17beta-estradiol-induced inhibition of VSMC proliferation in rats after vascular injury. Acta Physiological Sinica. 2003; 55(4):411-416.
18. Yang D., Tan Z., Liu P.Q., et al. 17β- estradiol inhibited vascular smooth muscle cells proliferation and c-fos expression: role of nitric oxide. Acta physiologica Sinica 2002; 54(1): 17-22.
19. Tan Z., Yang D., Lu W., et al. Effect of inhibition by 17β- estradiol on endothelin-induced proliferation of vascular smooth muscle cells. Chin J Appl Physiol 2001; 17(3): 251-254.
20. Wang T.H., Tan Z., and Yang D. Down-regulation of ETA receptor of vascular smooth muscle cells by 17β- estradiol. Acta physiologica Sinica 2001; 53(5): 380-384.
21. Wang T.H., Yang D., Liu P.Q., et al. 17β-estradiol induced vascular endothelial cells nitric oxide release and its mechanisms. Acta physiologica Sinica 2000; 52(6): 479-482.
22. Gong S.Z., Liu P.Q, Yang D., et al. The effect of conditioned growth medium of ventricular fibroblasts increase beating rate on cultured neonatal rats cardiomyocytes. Chin J Appl Physiol 2000; 16(2): 153-157.
23. Yang D., ZENG S., Liu W.L., et al. Lysophosphatidylcholine-induced platelet activation and the role of protein-tyrosine kinase and protein kinase C. Chin J Pharm and Toxic. 1999; 13(1): 49-52.
