Cidi Chen

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Research Assistant Professor of Biochemistry
Department of Biochemistry

Boston University School of Medicine
Silvio Conte Building, K621
72 E. Concord Street
Boston, MA. 02118

Phone: 617-638-4315

Fax: 617-638-5339

Email: cidichen@bu.edu

Education:

Ph.D., University of Illinois at Urban-Champaign

Research Interests: The mechanisms of brain aging in a rhesus monkey model and the functions of the anti-aging protein, Klotho.

1) Identify the proteases responsible for Klotho shedding. 2) Study the regulatory relationship of insulin and Klotho. 3) Characterization of Klotho promoter and Klotho gene regulation. 4) Decipher the role of Klotho in brain aging and identify the receptor for this anti-aging gene. 5) Examine the gene expression profiles of white and gray matter as well as single neurons obtained from young and old, behaviorally tested, rhesus monkeys to understand the mechanisms of age-related changes in brain using cDNA microarray and qRT-PCR analysis.

Representative Publications:

  1. Chen, C-D, Huff, ME, Matteson, J, Page, L, Phillips, R, Kelly, JW, Balch, WE., “Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization.”. EMBO J (2001) 20:6277-87.
  2. Oh, SY, Ellenstein, A, Chen, C-D, Hinman, JD, Berg, EA, Costello, CE, Yamin, R, Neve, RL and Abraham, CR (2005) The Amyloid Precursor Protein interacts with Notch receptors. J. Neurosci. Res. 82:32-42.
  3. Chen, C-D, Oh, SY, Hinman, JD and Abraham, CR. (2006) Visualization of APP dimerization and APP-Notch heterodimerization in living cells using bimolecular fluorescence complementation. J. Neurochem, 97:30-43.
  4. Chen, C-D, Podvin, S, Gillespie, E, Leeman, S and Abraham, CR. (2007) Insulin Stimulates the Cleavage and Release of the Extracellular Domain of Klotho via ADAM10 and ADAM17, PNAS. 104:19796-19801.
  5. Hinman, JD, Chen, C-D, Oh, S-Y, Hollander, W and Abraham, CR. (2008) Age-dependent accumulation of ubiquitinated CNP in myelin lipid rafts. Glia. 56:118-33.
  6. *Zerbinatti, CV, *Cordy, JM, *Chen, CD, Guillily, M, Suon, S, Ray, WJ, Seabrook, GR, Abraham, CR, Wolozin, B. (2008) Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. Mol Neurodegener. Mar 18;3:5.
Primary teaching affiliate
of BU School of Medicine