Abdulmaged M. Traish
Professor of Biochemistry
Departments of Biochemistry and Urology
Boston University School of Medicine
Center for Advanced Biomedical Research Building, W607
700 Albany Street
Boston, MA 02118
Phone: 617-638-4578
Fax: 617-638-5339
Email: atraish@bu.edu
Education
B.Sc, University of Tripoli, Tripoli, Libya
Ph.D., Boston University, Boston, MA
Research Interest
My research interests are focussed on understanding the biochemical and physiological mechanisms of male erectile function and female genital sexual arousal function. Understandng the pathophysiology of these disorders will be very important to developing new innovative strategies to treat patients with such disorders. To achieve our objective, we have developed a multidisciplinary approach to study the role of neurotransmitters and vasoactive agents and their cognate receptors in modulating penile corpus avernosum trabecular smooth muscle tone and erectile function and the vaginal muscularis and its role in regulating the hemodynmaics of vaginal and clitoral tissue. These experimental approach utilizes pharmacological, physiological and biochemical methods to better understand how tissue structure and the signal transduction mechanisms are integrated to modulate corpus cavernosum smooth muscle tone and vaginal and clitoral smooth muscle contractility. Our objective is to understand the mechanisms underlying male erectile function and female genital arousal functcion to develop pharmacological agents for potential treatment of sexual dysfunction.
Representative Publications
Traish AM., Kim, NN., Moreland, RB., and Goldstein, I.. Role of alpha-adrenergic receptors in erectile function. IJIR, 12: 48-63, 2000
Traish, AM., Kim, NN., Huang, Y-H., Goldstein I., and. Moreland RB. Cylic AMP regulates mRNA expression of alpha 1d and alpha 2a adrenergic receptors in cultured human corpus cavernosum smooth muscle cells. IJIR, 12: 41-47, 2000.
I. Saenz de Tejada, N. N. Kim, I. Goldstein and A. M. Traish.Regulation of pre-synaptic alpha-adrenergic activity in the corpus cavernosum. . IJIR 12: 20-25, 2000.
Traish AM, Moreland RB, Huang Y-H, Kim NN and Goldstein I. Development of human and rabbit vaginal smooth muscle cell cultures: Effects of vasoactive agents on intracellular levels of cyclic nucleotides. Mol Cell Biol Res Commun 2: 131-137, 2000.
Kim. NN., Goldstein.I., Robert Moreland, RB., and Traish, AM. Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum. IJIR 12: 26-36, 2000.
Lue, T., Goldstein, I and Traish, AM. Comparison of oral and intracavernosal vasoactive agents in penile erection. IJIR 12: 81-88, 2000.
Traish AM, . Kim NN, Goldstein I. and Moreland RB. Alpha adrenergic receptors in the penis: Identification, characterization and physiological function. J. Andrology 1999, 20: 671-682.
Cox JD, Kim NN, Traish AM, Christianson DW. Arginase-boronic acid complex highlights a physiological role in erectile function. Nat. Struct. Biol. 1999, 6:1043-1047.
Moreland RB, Goldstein I, Kim NN, Traish A. Sildenafil Citrate, a Selective Phosphodiesterase Type 5 Inhibitor: Trends Endocrinol Metab. 1999, 10:97-104.
Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology. 1999, 140:1861-8.
Traish AM, Gupta S , Gallant C, Huang Y-H, and IGoldstein I. Phentolamine mesylate relaxes penile corpus cavernosum tissue by adrenergic and non-adrenergic mechanisms. Int J Impot Res 1998; Dec; 10 (4): 215-223.
Azadzoi KM, Goldstein I, Siroky MB, Traish AM, Krane RJ, Saenz de Tejada I. Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction.J Urol 1998 Dec;160(6 Pt 1):2216-22.
Moreland RB, Gupta S, Goldstein I, Traish AM. Cyclic AMP modulates TGF-beta 1-induced fibrillar collagen synthesis in cultured human corpus cavernosum smooth muscle cells.Int J Impot Res 1998 Sep;10(3):159-63.
Sadeghi-Nejad H, Moreland RB, Traish AM, Nehra A, Azadzoi KM, Goldstein I. Preliminary report on the development and characterization of rabbit clitoral smooth muscle cell culture.Int J Impot Res 1998, Sep;10(3):165-9.
Park K, Moreland RB, Goldstein I, Atala A, Traish AM. Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1998 Aug 28;249(3):612-7
Newhall PM, Traish A, Moreland RB. Development of an organ culture experimental system to investigate collagen synthesis in corpora cavernosa. Int J Impot Res 1998 Jun;10(2):77-81.
Moreland RB, Goldstein I, Traish A. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells. Life Sci 1998;62(20):PL 309-18.
Gupta S, Moreland RB, Yang S, Gallant CM, Goldstein I, Traish AM. The expression of functional postsynaptic alpha2-adrenoceptors in the corpus cavernosum smooth muscle.Br J Pharmacol 1998 Mar;123(6):1237-45.
Gupta S, Salimpour P, Saenz de Tejada I, Daley J, Gholami S, Daller M, Krane RJ, Traish AM, Goldstein I A possible mechanism for alteration of human erectile function by digoxin: inhibition of corpus cavernosum sodium/potassium adenosine triphosphatase activity.J Urol 1998 May;159 (5):1529-36.
Moreland RB, Watkins MT, Nehra A, Huang Y-H, Munarriz R, Salimpour P,Goldstein I, and Traish AM. Oxygen tension modulates TGF-beta 1 expression and PGE production in human corpus cavernosum smooth muscle cells. Molecular Urology. 2: number 1, 1998, 41-47.
