GMS BI 751 Biochemistry and Cell Biology
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| Prereq: consent of instructor. Basic principles and concepts of medical school-level Biochemistry and Cell Biology in a one-semester course. Topics include protein structure and function; mechanisms of enzyme action; nutrition and metabolism; membrane structure and receptor signaling; cell cycle regulation; DNA and RNA structure and function; regulation of gene expression and techniques in Molecular Medicine. Clinical correlations are provided throughout the course. 6 credits. |
GMS BI 755/756 Biochemistry A, B
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| Prereq: organic chemistry or equivalent, and consent of instructor. This two-semester course provides the biochemical foundation for advanced studies in basic and clinical sciences. Topics presented in the first semester include the structure and function of macromolecules, the mechanisms of enzyme action, the metabolism of carbohydrates and lipids, as well as bioenergetics. The second semester continues with the metabolism of lipids, amino acids and nucleotides, the control of metabolic processes, the function of hormones, biochemical genetics, and transcriptional and translational events. 4 credits. |
GMS BI 759 Integrative Biochemistry
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| Prereq Biochemistry (BI755, BI756), Cell Biology (MS 753) and Molecular Biology (BI782) or equivalent and permission of instructor. An integrated view of biochemistry and the control of cellular and organismal functions with regard to nutrient utilization is the topic of the course. Obesity and diabetes are epidemics in most of the world and these have occurred largely in the last 2 decades. Understanding the how and the why of this is the goal of the course which focuses on the molecular events of metabolic regulation at numerous levels. 4 credits. |
GMS BI 776 Gene Targeting in Transgenic Mice
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| Prereq: BI 755, 756; MS 753; and consent of instructor. Introduction to the basic theory and practice of an approach applicable to many cell biology problems. Covers the following topics: early mouse development; gene targeting into mouse embryos; homologous recombination in embryonic stem cells; review of practical aspects of the transgenic technology; review of selected studies employing transgenic mice and chimeric (gene knockout) mice. Offered alternate years. 2 credits. |
GMS BI 778 Mechanisms of Cardiovascular Disease
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| Offered alternate years. TBA. 2 credits. |
GMS BI 782 Molecular Biology
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| Prereq: GMS BI 755, 756 or equivalent and consent of instructor. Advanced molecular biology using the current literature as a source of information. Emphasis is placed on relevant research techniques. Topics include DNA/RNA/protein synthesis and function analysis of genetic disorders, gene therapy, molecular biology of important cellular processes, and regulation of gene expression. 4 credits. |
GMS BI 786 Biochemical Mechanisms of Aging
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| Prereq: consent of instructor. Current issues and key research advances in the understanding of the biochemical processes involved in aging of mammals are discussed. Theories on aging are analyzed, and age-related changes in gene structure and expression are presented. Alterations in the function of the neuroendocrine and immune systems with aging are also discussed. Offered alternate years. 2 credits. |
GMS BI 787 Molecular Mechanisms of Growth and Development
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| Prereq: GMS BI 755, 756 or equivalent and consent of instructor. Examines the most recent advances in the molecular mechanisms involved in regulation of cell proliferation, differentiation, and development. Control of the cell cycle and regulation of the expression of differentiated function are discussed. The role of extracellular growth factors and nuclear transcriptional regulatory proteins are explored. Students present and actively discuss recent primary research articles. Offered alternate years. 2 credits. |
GMS BI 789 Physical Biochemistry
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| Prereq: consent of instructor. The structure of water, its role in protein or nucleic acid folding, as well as the part played by water or by its exclusion in biochemical reactions, forms the basis of the course. The role of uncharged vs. charged solutes, and the effect of enclosure of aqueous solutions of macromolecules in semipermeable membranes (i.e., modeling of a cell, as well as of the protein solutions within it) are also considered. Offered alternate years. 2 credits. |
| Prereq: GMS BI 755, 756 or equivalent and consent of instructor. |
GMS BI 854 Biochemistry Student Seminar
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| Required for all first- and second-year post-bachelor’s PhD biochemistry students and for all first-year MA, post-master’s PhD, and MD/PhD biochemistry students. Students present seminars on current topics in molecular and cellular biochemistry. The objective of this course is to develop oral presentation and critical thinking skills. 2 credits. |
GMS BI 793 Mass Spectrometry, Proteomics and Functional Genomics
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| Prereq BI 755, 756 or equivalent and permission of instructor. This course gives investigators the background necessary to effectively design mass spectrometric (MS) experiments and interpret data. Instrumentation is described at a level appropriate to graduate students in biochemistry; the structure of biological macromolecules is addressed as it applies to MS. Students gain a full understanding of modern MS and its effective use in their research. Lectures are devoted to instrumentation, ionization methods and applications to proteins, lipids, carbohydrates, glycoconjugates, nucleic acids and uses of the technology in proteomics, biotechnology and medicine. 2 credits. |
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