Proteomics, Glycomics and Lipidomics
Proteins, carbohydrates and lipids serve both structural and signaling roles; their identities and distributions vary with growth, development and disease. At cell and membrane surfaces and in the extracellular space, the interactions of cells are regulated by these classes of molecules. Within cells, they govern traffic between compartments.
Proteomics, glycomics and lipidomics investigate the phenotypes with respect to these compound classes in a given cell, tissue or organism, and the dynamics of their expression related to biological transformation, thus leading to understanding of intracellular and intercellular processes at the level of expression rather than extrapolation from genetic information. These studies are relevant to metabolic disorders and diseases such as diabetes, oxidative stress, cancers, neurological disorders, infectious diseases and atherosclerosis, as well as normal development and aging.
Among the faculty involved with such studies are:
- Dr. Catherine Costello (Proteins, Glycans and Lipids)
- Dr. Cheng Lin (Proteins, Glycans)
- Dr. Joseph Zaia (Glycosaminoglycans, Protein-GAG interactions)
