Roger Théberge, Sr. Research Scientist

Center for Biomedical Mass Spectrometry
Mass Spectrometry Resource
Boston University School of Medicine
670 Albany Street, Suite 504
Boston, MA 02118-2526 USA
(617)-638-6764
(617)-638-6761 (FAX)

Email: Roger Theberge

Recent Publications:

  • Ying, W.; Perlman, D. H.; Li, L.; Theberge, R.; Costello, C. E.; McComb, M. E. Highly efficient and selective enrichment of peptide subsets combining fluorous chemistry with reversed-phase chromatography. Rapid Commun Mass Spectrom 2009, 23, 4019-30. Link
  • Connors, L. H.; Prokaeva, T.; Lim, A.; Theberge, R.; Falk, R. H.; Doros, G.; Berg, A.; Costello, C. E.; O’Hara, C.; Seldin, D. C.; Skinner, M. Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis. Am Heart J 2009, 158, 607-14. Link
  • Lavatelli, F.; Perlman, D. H.; Spencer, B.; Prokaeva, T.; McComb, M. E.; Theberge, R.; Connors, L. H.; Bellotti, V.; Seldin, D. C.; Merlini, G.; Skinner, M.; Costello, C. E. Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol Cell Proteomics 2008, 7, 1570-83. Link
  • Kingsbury, J. S.; Laue, T. M.; Klimtchuk, E. S.; Theberge, R.; Costello, C. E.; Connors, L. H. The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation. J Biol Chem 2008, 283, 11887-96. Link
  • Connors, L. H.; Jiang, Y.; Budnik, M.; Theberge, R.; Prokaeva, T.; Bodi, K. L.; Seldin, D. C.; Costello, C. E.; Skinner, M. Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chains. Biochemistry 2007, 46, 14259-71. Link
  • Rosenzweig, M.; Skinner, M.; Prokaeva, T.; Theberge, R.; Costello, C.; Drachman, B. M.; Connors, L. H. A new transthyretin variant (Glu61Gly) associated with cardiomyopathy. Amyloid 2007, 14, 65-71. Link
  •  

  • Kingsbury, J. S.; Klimtchuk, E. S.; Theberge, R.; Costello, C. E.; Connors, L. H. Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin. Protein Expr Purif 2007, 53, 370-7. Link
  •  

  • Kingsbury, J. S.; Theberge, R.; Karbassi, J. A.; Lim, A.; Costello, C. E.; Connors, L. H. Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry. Anal Chem 2007, 79, 1990-8. Link
  •  

  • Sendak, R. A.; Ganesa, C.; Lee, K. L.; Harrahy, J. J.; Theberge, R.; Morgan, C. J.; Cole, E. S.; Kohn, L. D.; Mattaliano, R. J. The effect of posttranslational modifications on the in vitro activity of recombinant human thyroid-stimulating hormone. Thyroid 2003, 13, 1091-101. Link
  •  

  • Lim, A.; Sengupta, S.; McComb, M. E.; Theberge, R.; Wilson, W. G.; Costello, C. E.; Jacobsen, D. W. In vitro and in vivo interactions of homocysteine with human plasma transthyretin. J Biol Chem 2003, 278, 49707-13. Link
  •  

  • Lim, A.; Prokaeva, T.; McComb, M. E.; O’Connor, P. B.; Theberge, R.; Connors, L. H.; Skinner, M.; Costello, C. E. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis. Anal Chem 2002, 74, 741-51. Link
  •  

  • Connors, L. H.; Richardson, A. M.; Theberge, R.; Costello, C. E. Tabulation of transthyretin (TTR) variants as of 1/1/2000. Amyloid 2000, 7, 54-69. Link
  •  

  • Theberge, R.; Connors, L. H.; Skinner, M.; Costello, C. E. Detection of transthyretin variants using immunoprecipitation and matrix-assisted laser desorption/ionization bioreactive probes: a clinical application of mass spectrometry. J Am Soc Mass Spectrom 2000, 11, 172-5. Link
  •  

  • Connors, L. H.; Theberge, R.; Skare, J.; Costello, C. E.; Falk, R. H.; Skinner, M. A new transthyretin variant (Ser23Asn) associated with familial amyloidosis in a Portuguese patient. Amyloid 1999, 6, 114-8. Link
  •  

  • Theberge, R.; Connors, L.; Skare, J.; Skinner, M.; Falk, R. H.; Costello, C. E. A new amyloidogenic transthyretin variant (Val122Ala) found in a compound heterozygous patient. Amyloid 1999, 6, 54-8. Link
  •  

  • Theberge, R.; Connors, L.; Skinner, M.; Skare, J.; Costello, C. E. Characterization of transthyretin mutants from serum using immunoprecipitation, HPLC/electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry. Anal Chem 1999, 71, 452-9. Link
  •  

    Primary teaching affiliate
    of BU School of Medicine