Obesity Journal Club

Obesity Journal Club 10/02/18 at 12pm in M&V 240

The Obesity Journal Club will meet on Tuesday, October 2nd from 12-1pm in M&V 240 and via WebEx (see details below).

A light snack will be served – please bring your own beverage.

Presenter: Aviva Must, Ph.D
Article Title: Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children
Authors/Journal: Tun et al. (2018) in Canadian Medical Association Journal (CMAJ).

Article Abstract

Background: Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight.

Methods: From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants.

Results: Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score (p = 0.02) and with increased odds of overweight or obesity (p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation (p = 0.2).

Conclusions: Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3–4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association.

WebEx Information
Meeting link: https://tufts.webex.com/tufts/j.php?MTID=mad23e0271c7ad84be82e132389fea1c6
Audio connection: +1-617-627-6767
Meeting number (access code): 735 529 375
Meeting password: znnHb536

The Obesity Journal Club is a program of the Boston Nutrition Obesity Research Center’s (BNORC). Aviva Must serves as the faculty facilitator. The general format includes the presentation, critique, and (we hope) thoughtful discussion of a current article from the peer-reviewed obesity literature. Faculty and students in the greater Boston area are welcome to attend and present. It is also possible to connect by WebEx and participate virtually—upon request.

Announcements for each meeting will come ~1 week in advance and will specify the paper we will review and critique. For those at Tufts, light snacks are served but please bring your own beverage. Obesity Journal Club will meet from 12-1pm on the 1st and 3rd Tuesday of every month from September to May.

Obesity Journal Club is participatory. We will ask for student and faculty volunteers to sign up and present an article of their choice at future meetings. Assistance in selecting an article for presentation is available. This is a great opportunity for students to develop presentation skills in a friendly low-risk environment. Sign up for the Fall meetings will take place at our first meeting on September 18th.

If you wish to be added to (or removed from) the Obesity Journal Club listserv, please email Ariella.Korn@tufts.edu or Katherine.Rancano@tufts.edu.