Obesity Journal Club

Obesity Journal Club 4/16/2019 at 12pm in M&V 240

The Obesity Journal Club will meet on Tuesday, April 16th, from 12-1pm in M&V 240 and via WebEx (see details below).
A light snack will be served – please bring your own beverage.

Presenter: Violeta Chacon, Doctoral Student
Article Title: Exposure to improved nutrition from conception to age 2 years and adult cardiometabolic disease risk: a modelling study
Authors/Journal: Ford, Nicole D., et al. The Lancet Global Health 6.8 (2018): e875-e884.
DOI: https://doi.org/10.1016/S2214-109X(18)30231-6

Article Abstract

Background Low-income and middle-income countries with populations that are chronically undernourished in early life are undergoing a nutrition transition and are experiencing an epidemic of cardiometabolic disease. These dual burdens are thought to be causally related; therefore, the extent to which improvements in early-life nutrition can offset adult-onset disease is important. The aim of this study was to examine whether improvement of protein-energy nutrition from conception to age 2 years can attenuate the risk of cardiometabolic disease.

Methods We followed up a cohort of 2392 individuals born between Jan 1, 1962, and Feb 28, 1977, in four villages in Guatemala who had participated in a cluster-randomised protein-energy nutritional supplementation (Atole) trial. Of 1661 participants available for follow-up from Feb 26, 2015, to April 29, 2017, we studied 684 women and 455 men. We assessed cardiometabolic disease risk at ages 37–54 years using anthropometry, fasting and post-challenge glucose, fasting lipid concentrations, and blood pressure. We used generalised linear and logistic regression modelling to estimate the effect of Atole from conception to age 2 years (the first 1000 days) on cardiometabolic disease risk.

Findings Exposure to Atole from conception to age 2 years was associated with increased fatness (body-mass index [1·29 kg/m², 95% CI 0·08 to 2·50], body fat [1·73%, 0·20 to 3·26], and obesity [odds ratio 1·94, 1·11 to 3·40]), diastolic blood pressure (1·59 mm Hg, –0·74 to 3·92), and blood lipids (total cholesterol [10·10 mg/dL, 0·80 to 19·40] and non-HDL cholesterol [10·41 mg/dL, 1·51 to 19·31]), reduced post-challenge glucose (–5·84 mg/dL, –12·51 to 0·83), and reduced odds of diabetes (odds ratio 0·46, 0·21 to 0·97). We found stratum heterogeneity by sex in pooled models for non-HDL cholesterol (4·34 mg/dL, 95% CI –6·86 to 15·55 for women vs 19·84 mg/dL, 5·86 to 33·82 for men) and post-challenge glucose (–0·19 mg/dL, –8·63 to 8·24 for women vs –13·10 mg/dL, –23·64 to –2·56 for men). p values for interaction of sex and exposure to Atole from conception to age 2 years were 0·09 and 0·04, respectively.

Interpretation Improved protein-energy nutrition from conception to the 2nd birthday reduced the odds of diabetes at ages 37–54 years; however, this protein-energy supplementation also increased the risk of obesity and several obesity related conditions. Our findings suggest a mixed ability of protein-energy nutritional supplementation in early life to prevent adult cardiometabolic disease incidence in the context of high childhood stunting and high adult overweight and obesity.

WebEx Information
Join by phone: 617-627-6767 US (Access code: 737 820 064)
Meeting number (access code):737 820 064
Meeting password: tibP3j38

The Obesity Journal Club is a program of the Boston Nutrition Obesity Research Center’s (BNORC). Aviva Must serves as the faculty facilitator. The general format includes the presentation, critique, and (we hope) thoughtful discussion of a current article from the peer-reviewed obesity literature. Faculty and students in the greater Boston area are welcome to attend and present. It is also possible to connect by WebEx and participate virtually—upon request.

Announcements for each meeting will come ~1 week in advance and will specify the paper we will review and critique. For those at Tufts, light snacks are served but please bring your own beverage. Obesity Journal Club will meet from 12-1pm on the 1st and 3rd Tuesday of every month from September to May.

Obesity Journal Club is participatory. We will ask for student and faculty volunteers to sign up and present an article of their choice at future meetings. Assistance in selecting an article for presentation is available. This is a great opportunity for students to develop presentation skills in a friendly low-risk environment. Sign up for the Fall meetings will take place at our first meeting on September 18th.

If you wish to be added to (or removed from) the Obesity Journal Club listserv, please email Ariella.Korn@tufts.edu or Katherine.Rancano@tufts.edu.