Complete List of Published Work in MyBibliography
2024
2023
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Berical A, Beermann ML, Wang F, Bawa PS, Kohn A, Ysasi AB, Kiyokawa H, Matte TM, Randell SH, Varelas X, Hawkins FJ, Kotton DN. Cell Stem Cell. 2023 Sep 7;30(9):1199-1216.e7. doi: 10.1016/j.stem.2023.07.014. Epub 2023 Aug 24. PMID: 37625411
Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer. Khan MM, Frustino J, Villa A, Nguyen BC, Woo SB, Johnson WE, Varelas X, Kukuruzinska M, Monti S. Hum Genomics. 2023 Aug 4;17(1):72. doi: 10.1186/s40246-023-00519-y. PMID: 37542347
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer. Reed ER, Jankowski SA, Spinella AJ, Noonan V, Haddad R, Nomoto K, Matsui J, Bais MV, Varelas X, Kukuruzinska MA, Monti S. Transl Res. 2023 Oct;260:46-60. doi: 10.1016/j.trsl.2023.05.007. Epub 2023 Jun 21. PMID: 37353110
Structure learning for gene regulatory networks. Federico A, Kern J, Varelas X, Monti S. PLoS Comput Biol. 2023 May 18;19(5):e1011118. doi: 10.1371/journal.pcbi.1011118. eCollection 2023 May. PMID: 37200395
Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. Ning B, Tilston-Lunel AM, Simonetti J, Hicks-Berthet J, Matschulat A, Pfefferkorn R, Spira A, Edwards M, Mazzilli S, Lenburg ME, Beane JE, Varelas X. J Exp Clin Cancer Res. 2023 May 8;42(1):116. doi: 10.1186/s13046-023-02674-5. PMID: 37150829
Polarity in respiratory development, homeostasis and disease. Tilston-Lunel AM, Varelas X. Curr Top Dev Biol. 2023;154:285-315. doi: 10.1016/bs.ctdb.2023.02.004. Epub 2023 Mar 15. PMID: 37100521
Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration. Raslan AA, Pham TX, Lee J, Hong J, Schmottlach J, Nicolas K, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. bioRxiv. 2023 Jan 20:2023.01.17.523179. doi: 10.1101/2023.01.17.523179. Preprint.PMID: 36712020
Generation of human alveolar epithelial type I cells from pluripotent stem cells. Kern Burgess CL, Huang J, Bawa P, Alysandratos KD, Minakin K, Morley MP, Babu A, Villacorta-Martin C, Hinds A, Thapa BR, Wang F, Matschulat AM, Morrisey EE, Varelas X, Kotton DN. bioRxiv. 2023 Jan 20:2023.01.19.524655. doi: 10.1101/2023.01.19.524655. Preprint.PMID: 36711505
2022
Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas. Kern JG, Tilston-Lunel AM, Federico A, Ning B, Mueller A, Peppler GB, Stampouloglou E, Cheng N, Johnson RL, Lenburg ME, Beane JE, Monti S, Varelas X. Nat Commun. 2022 Nov 28;13(1):7198. doi: 10.1038/s41467-022-34864-8. PMID: 36443313
Virtual screening for small-molecule pathway regulators by image-profile matching. Rohban MH, Fuller AM, Tan C, Goldstein JT, Syangtan D, Gutnick A, DeVine A, Nijsure MP, Rigby M, Sacher JR, Corsello SM, Peppler GB, Bogaczynska M, Boghossian A, Ciotti GE, Hands AT, Mekareeya A, Doan M, Gale JP, Derynck R, Turbyville T, Boerckel JD, Singh S, Kiessling LL, Schwarz TL, Varelas X, Wagner FF, Kafri R, Eisinger-Mathason TSK, Carpenter AE. Cell Syst. 2022 Sep 21;13(9):724-736.e9. doi: 10.1016/j.cels.2022.08.003. Epub 2022 Sep 2. PMID: 36057257
Basal extrusion of single-oncogenic mutant cells induces dome-like structures with altered microenvironments. Shirai T, Sekai M, Kozawa K, Sato N, Tanimura N, Kon S, Matsumoto T, Murakami T, Ito S, Tilston-Lunel A, Varelas X, Fujita Y. Cancer Sci. 2022 Nov;113(11):3710-3721. doi: 10.1111/cas.15483. Epub 2022 Aug 30. PMID: 35816400
Verteporfin protects against Th17 cell-mediated EAE independently of YAP inhibition. Brosinsky P, Leister H, Cheng N, Varelas X, Visekruna A, Luu M. Eur J Immunol. 2022 Sep;52(9):1523-1526. doi: 10.1002/eji.202149564. Epub 2022 Jul 25. PMID: 35776890
Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Vittoria MA, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell JD, Lang D, Xu X, Ceol CJ, Varelas X, Ganem NJ. Nat Commun. 2022 Jun 29;13(1):3732. doi: 10.1038/s41467-022-31399-w. PMID: 35768444
Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, Farmer SR. Life Sci Alliance. 2022 Feb 18;5(5):e202101286. doi: 10.26508/lsa.202101286. Print 2022 May. PMID: 35181634
Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Am J Physiol Lung Cell Mol Physiol. 2022 Feb 9. doi: 10.1152/ajplung.00325.2021. Online ahead of print. PMID: 35137631
Inhibition of LSD1 attenuates oral cancer development and promotes therapeutic efficacy of immune checkpoint blockade and Yap/Taz inhibition. Alhousami T, Diny M, Ali F, Shin J, Kumar G, Kumar V, Campbell J, Noonan V, Hanna G, Denis GV, Monti S, Kukuruzinska MA, Varelas X, Bais MV. Mol Cancer Res. 2022 Feb 1:molcanres.0310.2021. doi: 10.1158/1541-7786.MCR-21-0310. Online ahead of print. PMID: 35105672
2021
The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap. Baldan S, Meriin AB, Yaglom J, Alexandrov I, Varelas X, Xiao ZJ, Sherman MY.
J Cell Sci. 2021 Dec 1;134(23):jcs259107. doi: 10.1242/jcs.259107. Epub 2021 Dec 2. PMID: 34761265
Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Cell Rep. 2021 Aug 31;36(9):109636. doi: 10.1016/j.celrep.2021.109636. PMID: 34469722
Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Cell Rep. 2021 Jul 13;36(2):109347. doi: 10.1016/j.celrep.2021.109347. PMID: 34260916
Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations. Dela Cruz A*, Kartha V*, Tilston-Lunel A*, Mi R, Reynolds TL, Mingueneau M, Monti S, Jensen JL, Skarstein K, Varelas X, Kukuruzinska MA. Sci Rep. 2021 May 27;11(1):11154. doi: 10.1038/s41598-021-90569-w. PMID: 34045583
Aberrant epithelial polarity cues drive the development of precancerous airway lesions. Tilston-Lunel A, Mazzilli S, Kingston NM, Szymaniak AD, Hicks-Berthet J, Kern JG, Abo K, Reid ME, Perdomo C, Wilson AA, Spira A, Beane J, Varelas X. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2019282118. doi: 10.1073/pnas.2019282118. PMID: 33903236
ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation. Jones DL, Meridew JA, Link PA, Ducharme MT, Lydon KL, Choi KM, Caporarello N, Tan Q, Diaz Espinosa AM, Xiong Y, Lee JH, Ye Z, Yan H, Ordog T, Ligresti G, Varelas X, Tschumperlin DJ. J Cell Biol. 2021 May 3;220(5):e202007152. doi: 10.1083/jcb.202007152. PMID: 33625469
Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Front Cell Dev Biol. 2021 Jan 7;8:608044. doi: 10.3389/fcell.2020.608044. eCollection 2020. PMID: 33490071
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Mol Cell. 2021 Jan 7;81(1):212. doi: 10.1016/j.molcel.2020.12.028. PMID: 33417854
2020
Naturally occurring hotspot cancer mutations in Gα13 promote oncogenic signaling. Maziarz M, Federico A, Zhao J, Dujmusic L, Zhao Z, Monti S, Varelas X, Garcia-Marcos M. J Biol Chem. 2020 Dec 4;295(49):16897-16904. doi: 10.1074/jbc.AC120.014698. Epub 2020 Oct 27. PMID: 33109615
Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Zeng C, Motta-Ribeiro GC, Hinoshita T, Lessa MA, Winkler T, Grogg K, Kingston NM, Hutchinson JN, Sholl LM, Fang X, Varelas X, Layne MD, Baron RM, Vidal Melo MF. Anesthesiology. 2020 Nov 1;133(5):1060-1076. doi: 10.1097/ALN.0000000000003491. PMID: 32796202
The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFbeta Signaling. Pseftogas A, Xanthopoulos K, Poutahidis T, Ainali C, Dafou D, Panteris E, Kern JG, Varelas X, Hardas A, Gonidas C, Tsingotjidou A, Hatzivassiliou E, Mosialos G. Cancers (Basel). 2020 Jul 24;12(8):2047. doi: 10.3390/cancers12082047. PMID: 32722292
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Dey A, Varelas X, Guan KL. Nat Rev Drug Discov. 2020 Jul;19(7):480-494. doi: 10.1038/s41573-020-0070-z. Epub 2020 Jun 17. PMID: 32555376
The in vivo genetic program of murine primordial lung epithelial progenitors. Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R 3rd, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kańduła MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN. Nat Commun.2020 Jan 31;11(1):635. doi: 10.1038/s41467-020-14348-3. PMID: 32005814
Yap suppresses T-cell function and infiltration in the tumor microenvironment. Stampouloglou E, Cheng N, Federico A, Slaby E, Monti S, Szeto GL, Varelas X. PLoS Biol. 2020 Jan 13;18(1):e3000591. doi: 10.1371/journal.pbio.3000591. eCollection 2020 Jan. PMID: 31929526
2019
Identification of candidate cancer drivers by integrative Epi-DNA and Gene Expression (iEDGE) data analysis. Li A, Chapuy B, Varelas X, Sebastiani P, Monti S. Sci Rep.2019 Nov 15;9(1):16904. doi: 10.1038/s41598-019-52886-z. PMID: 31729402
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD Jr, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Sci Transl Med. 2019 Oct 30;11(516):eaau6296. doi: 10.1126/scitranslmed.aau6296. PMID: 31666402
TGFbeta-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ. J Cell Sci. 2019 Oct 18;132(20):jcs233486. doi: 10.1242/jcs.233486. PMID: 31527052
TAZ Forces Lateral Inhibition. Kern JG, Varelas X. Dev Cell. 2019 Mar 25;48(6):748-750. doi: 10.1016/j.devcel.2019.03.006.
PMID: 30913406
CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features. Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S. Front Genet. 2019 Feb 19;10:121. doi: 10.3389/fgene.2019.00121. eCollection 2019. PMID: 30838036
Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells. Kingston NM, Tilston-Lunel AM, Hicks-Berthet J, Varelas X. Methods Mol Biol. 2019;1893:107-113. doi: 10.1007/978-1-4939-8910-2_9. PMID: 30565129
2018
Phosphatidic Acid Signals via the Hippo Pathway. Stampouloglou E, Varelas X. Mol Cell. 2018 Oct 18;72(2):205-206. doi: 10.1016/j.molcel.2018.10.004. PMID: 30340020
Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer. Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Genome Med. 2018 Jul 20;10(1):54. doi: 10.1186/s13073-018-0569-7. PMID: 30029671
Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation. Meriin AB, Narayanan A, Meng L, Alexandrov I, Varelas X, Cissé II, Sherman MY. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7043-E7052. doi: 10.1073/pnas.1803130115. Epub 2018 Jul 9. PMID: 29987014
Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells. Yang CS, Stampouloglou E, Kingston NM, Zhang L, Monti S, Varelas X. EMBO Rep. 2018 Jun;19(6):e43577. doi: 10.15252/embr.201643577. Epub 2018 Apr 16. PMID: 29661856
2017
Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis. Toyama T, Looney AP, Baker BM, Stawski L, Haines P, Simms R, Szymaniak AD, Varelas X, Trojanowska M. J Invest Dermatol. 2018 Jan;138(1):78-88. doi: 10.1016/j.jid.2017.08.024. Epub 2017 Sep 1. PMID: 28870693
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM. Sci Transl Med. 2017 Dec 13;9(420):eaal3765. doi: 10.1126/scitranslmed.aal3765. PMID: 29237758
Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Alsaqer SF, Tashkandi MM, Kartha VK, Yang YT, Alkheriji Y, Salama A, Varelas X, Kukuruzinska M, Monti S, Bais MV. Oncotarget. 2017 Jul 27;8(43):73372-73386. doi: 10.18632/oncotarget.19637. eCollection 2017 Sep 26. PMID: 29088714.
Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O’Carroll D, Jones MR. J Clin Invest. 2017 Oct 2;127(10):3866-3876. doi: 10.1172/JCI94639. Epub 2017 Sep 18. PMID: 28920925
Integrin-FAK-CDC42-PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells. Hicks-Berthet J, Varelas X. Bioessays. 2017 Oct;39(10):10.1002/bies.201700116. doi: 10.1002/bies.201700116. Epub 2017 Sep 11. PMID: 28891248
Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L628-L647. doi: 10.1152/ajplung.00173.2017. Epub 2017 Jun 22. PMID: 28642262
The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland. Szymaniak AD, Mi R, McCarthy SE, Gower AC, Reynolds TL, Mingueneau M, Kukuruzinska M, Varelas X. Elife. 2017 May 11;6:e23499. doi: 10.7554/eLife.23499. PMID: 28492365
Systematic morphological profiling of human gene and allele function via Cell Painting. Rohban MH, Singh S, Wu X, Berthet JB, Bray MA, Shrestha Y, Varelas X, Boehm JS, Carpenter AE. Elife. 2017 Mar 18;6:e24060. doi: 10.7554/eLife.24060. PMID: 28315521
TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression. Jorgenson AJ, Choi KM, Sicard D, Smith KM, Hiemer SE, Varelas X, Tschumperlin DJ. Am J Physiol Cell Physiol. 2017 Mar 1;312(3):C277-C285. doi: 10.1152/ajpcell.00205.2016. Epub 2016 Nov 23. PMID: 27881410 Free PMC article.
2016
Altered RNA editing in 3′ UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors. Zhang L, Yang CS, Varelas X, Monti S. Sci Rep. 2016 Mar 16;6:23226. doi: 10.1038/srep23226. PMID: 26980570 Free PMC article.
2015
Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Dev Cell. 2015 Aug 10;34(3):283-96. doi: 10.1016/j.devcel.2015.06.020. Epub 2015 Jul 30. PMID: 26235047 Free PMC article.
A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma. Hiemer SE, Zhang L, Kartha VK, Packer TS, Almershed M, Noonan V, Kukuruzinska M, Bais MV, Monti S, Varelas X. Mol Cancer Res. 2015 Jun;13(6):957-68. doi: 10.1158/1541-7786.MCR-14-0580. Epub 2015 Mar 20. PMID: 25794680
Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling. Narimatsu M, Samavarchi-Tehrani P, Varelas X*, Wrana JL*. Dev Cell. 2015 Mar 9;32(5):652-6. doi: 10.1016/j.devcel.2015.02.019. PMID: 25758863 Free article.
Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Development. 2015 Jan 15;142(2):258-67. doi: 10.1242/dev.116855. PMID: 25564622
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. PMID: 25502501
2014
Head and neck cancer: from research to therapy and cure. Varelas X, Kukuruzinska MA. Ann N Y Acad Sci. 2014 Dec;1333:1-32. doi: 10.1111/nyas.12613. PMID: 25532687
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV. Dev Cell. 2014 Jul 28;30(2):137-50. doi: 10.1016/j.devcel.2014.06.003. Epub 2014 Jul 17. PMID: 25043473
Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling. Varelas X, Bouchie MP, Kukuruzinska MA. Glycobiology. 2014 Jul;24(7):579-91. doi: 10.1093/glycob/cwu031. Epub 2014 Apr 17. PMID: 24742667
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Varelas X. Development. 2014 Apr;141(8):1614-26. doi: 10.1242/dev.102376. PMID: 24715453
The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells.Hiemer SE, Szymaniak AD, Varelas X. J Biol Chem. 2014 May 9;289(19):13461-74. doi: 10.1074/jbc.M113.529115. Epub 2014 Mar 19. PMID: 24648515
2013
Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells. Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL. Cell Rep. 2013 Dec 26;5(6):1611-24. doi: 10.1016/j.celrep.2013.11.021. Epub 2013 Dec 12. PMID: 24332857
The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7. Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X. J Biol Chem. 2014 Jan 24;289(4):1886-91. doi: 10.1074/jbc.C113.529362. Epub 2013 Dec 9. PMID: 24324261
The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren’s syndrome. Enger TB, Samad-Zadeh A, Bouchie MP, Skarstein K, Galtung HK, Mera T, Walker J, Menko AS, Varelas X, Faustman DL, Jensen JL, Kukuruzinska MA. Lab Invest. 2013 Nov;93(11):1203-18. doi: 10.1038/labinvest.2013.114. Epub 2013 Sep 30.
PMID: 24080911
N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration. Liu G, Sengupta PK, Jamal B, Yang HY, Bouchie MP, Lindner V, Varelas X, Kukuruzinska MA. J Biol Chem. 2013 Jul 12;288(28):20217-27. doi: 10.1074/jbc.M113.473785. Epub 2013 May 23. PMID: 23703614
Stem cell regulation by the Hippo pathway. Hiemer SE, Varelas X. Biochim Biophys Acta. 2013 Feb;1830(2):2323-34. doi: 10.1016/j.bbagen.2012.07.005. Epub 2012 Jul 20. PMID: 22824335
2012
Coordinating developmental signaling: novel roles for the Hippo pathway. Varelas X, Wrana JL. Trends Cell Biol. 2012 Feb;22(2):88-96. doi: 10.1016/j.tcb.2011.10.002. Epub 2011 Dec 5. PMID: 22153608
Integrating developmental signals: a Hippo in the (path)way. Mauviel A, Nallet-Staub F, Varelas X. Oncogene. 2012 Apr 5;31(14):1743-56. doi: 10.1038/onc.2011.363. Epub 2011 Aug 29. PMID: 21874053
2011&before
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F. Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16. PMID: 21683433
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J, Wrana JL. Dev Cell. 2010 Dec 14;19(6):831-44. doi: 10.1016/j.devcel.2010.11.012. PMID: 21145499
The Hippo pathway regulates Wnt/beta-catenin signaling. Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L. Dev Cell. 2010 Apr 20;18(4):579-91. doi: 10.1016/j.devcel.2010.03.007. PMID: 20412773
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL.
J Biol Chem. 2010 Feb 26;285(9):6308-15. doi: 10.1074/jbc.M109.044537. Epub 2009 Dec 21.
PMID: 20026602
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