Inflammation & ECM
Inflammation: Inflammatory processes contribute to tissue repair and resolving invasion by pathogens or toxic substances. Chronic inflammation however, causes tissue damage and has been identified as contributing to a host of diseases including cardiovascular, pulmonary, neurodegenerative, metabolic/obesity-related diseases and cancer. Using state of the art approaches, researchers in our Department examine the molecular and cellular pathways contributing to the chronic inflammation associated with these diseases.
Extracellular matrix (ECM): Critical to the evolution of multicellular organisms was acquiring the ability to synthesize connections between cells. The ECM integrates cells into tissues, tissues into organs and organs into the organism. The ECM is an extension of the cell and participates actively in functions including development, migration, proliferation, metabolism and stabilization of tissue structure. Our research examines fundamental mechanisms of vascular and eye injury, organ fibrosis, and mechanical signaling that contribute to cellular and tissue dysfunction.
Faculty conducting research in these areas:
- Matthew Layne (Transcriptional regulation, atherosclerosis, fibrosis)
- Valentina Perissi (Transcriptional regulation of inflammatory responses, ubiquitin signaling)
- Peter Polgar (Receptor structure/function)
- Barbara Schreiber (Elastin, serum amyloid A, Atherosclerosis)
- Vickery Trinkaus-Randall (Glycosaminoglycans)
- Joseph Zaia (Glycosaminoglycans)