- Title Instructor, Abraham Lab
- Education MS: Medical Sciences, Tel Aviv University, Israel
PhD in Oral Biology and Physiology and Pharmacology, from Tel Aviv University, Israel
- Office K112
- Email firstname.lastname@example.org
- Area of Interest Alzheimer’s disease and aging, Neuroprotection, Klotho transcriptional regulation
I joined Dr. Abraham’s lab as a postdoctoral associate in 2011. Since then I have been studying the roles the anti-aging protein Klotho and the Amyloid Precursor Protein (APP) in the brain under conditions associated with Alzheimer’s disease (AD) and Multiple Sclerosis (MS). I have been investigating the neuroprotective properties of Klotho under oxidative stress conditions in primary neurons and we identified the crucial involvement of the members of the redox system in Klotho-induced neuroprotection. I also have been studying the link between Klotho and myelin, and we showed recently the re-myelinating effect of Klotho, a finding that has a clinical importance to MS. In order to therapeutically exploit the neuroprotective properties of Klotho, we conduct translational studies through the screening and testing of Klotho enhancing compounds in in vitro, ex-vivo and in vivo systems.
Another research focus is the reduction of the accumulation of neurotoxic amyloid beta (Abeta), which is the main component of the amyloid plaques found in the brains of Alzheimer patients. This research topic is based on the regulation of APP phosphorylation and processing by small molecules that subsequently leads to a decreases production of amyloid beta. We identified recently a new signaling pathway involved in the regulation of APP processing that presents a novel therapeutic approach to prevent or treat the pathogenesis associated with AD.
Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. Vitam Horm. 2016; 101:215-38. PMID: 27125744.
Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR. The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination. J Mol Neurosci. 2015 Oct; 57(2):185-96. PMID: 26067431.
Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 2014 Sep 2; 53(34):5579-87. PMID: 25110992.
Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92. PMID: 25043464.
Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014 Aug 29; 289(35):24700-15. PMID: 25037225.
Chen CD, Li H, Liang J, Hixson K, Zeldich E, Abraham CR. The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci. 2015 Jan; 55(1):76-90. PMID: 24907942.
Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39. PMID: 23365232.
Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem. 2012 Sep; 4(13):1671-9. PMID: 22924505.
So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87. PMID: 22822474.
King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. Biochem J. 2012 Jan 1; 441(1):453-61. PMID: 21939436.
Complete list can be found at BU Profiles