• Title Postdoctoral Associate
  • Office K206, Garcia-Marcos Lab
  • Phone 617-638-4037
  • Area of Interest G-protein signaling, developmental biology

I have been a postdoc in Mikel Garcia-Marcos laboratory in the Department of Biochemistry at Boston University School of Medicine since 2013. I study mechanisms of signal transduction executed by heterotrimeric G proteins. I first encountered G proteins when I was a graduate student in Biochemistry at the University of Burgundy (Dijon, France). At that time, I was working on a new regulator of small G proteins and actin cytoskeleton remodeling during tumor progression. This early experience spurred my interest in G proteins, so I decided to pursue a postdoc in this area. Although the basics of signaling through G proteins have been established a while ago, new exciting concepts of signaling modulation are currently emerging. Our team is particularly interested in a brand new class of alternative activators of G proteins called non-receptor GEFs. Another main focus of the lab is the characterization of abnormal G protein functions associated with human disease.

My work uses a combination of “old fashion” biochemistry with cellular and in vivo models. Since I joined the lab, I have learnt a wide array of techniques to study G protein biochemistry: in vitro enzymatic assays, yeast-based signaling assays and BRET-based signaling assays in mammalian cells. In parallel to that, I trained in the use of Xenopus laevis (frogs) as a model of vertebrate embryonic development in the lab of Isabel Dominguez on the BU medical campus. A good example of this combination of approaches is shown in a recently published paper (Marivin et al., Sci. Signal.) where we used frog-based bioassays, in vitro biochemistry, and BRET-based assays to elucidate the molecular basis of G protein dysregulation in a congenital disorder characterized by craniofacial developmental defects. Another ongoing project focuses on elucidating the role of a novel G protein regulator in the development of hydrocephalus, another inherited disorder. My personal goal is to pursue a career in this field to ultimately help for the design of new therapies targeting G protein signaling.

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