• Title Research Scientist—Garcia-Marcos Lab
  • Education University of Burgundy (Dijon, France)
  • Office K206, Garcia-Marcos Lab
  • Phone (617) 358-4397
  • Area of Interest G protein signaling, actin cytoskeleton
    developmental biology

My research focuses on understanding basic principles of signal transduction mediated by heterotrimeric G proteins and studying their implication in human disease. I use a multidimensional approach combining in vitro biochemistry, cell biology and developmental biology with two model organisms: frogs (Xenopus laevis) and zebrafish. With this approach, I characterized the molecular basis of G protein signaling dysfunctions associated with cancer and birth defects. I discovered a novel mechanism of G protein activation that coordinates actomyosin contractility during epithelium morphogenesis. This mechanism plays an important role during the embryonic development to establish the correct structure of the brain. Dysfunctions in this process induces brain malformations and causes hydrocephalus, which is major cause of childhood morbidity and mortality. My personal goal is to pursue a career in this field to better understand how G proteins work in cells and tissues and help for the design of novel cures.

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