Charting the molecular networks of cells and tissues
My laboratory develops and applies advanced proteomic, molecular genetic, genomic and bioinformatic technologies to investigate the molecular associations and biological roles of the many varied macromolecules present in different cells, tissues and organisms. Our research team has outstanding skills in state-of-the-art protein mass spectrometry and other high-throughput techniques for investigating molecular interaction networks in a global systems-wide manner. Our group aims to generate comprehensive maps of the physical and functional “interactomes” of informative models, ranging from unicellular microbes like yeast or the bacterium E. coli to more complex metazoans such as worm, mouse and (increasingly) human. We expect these maps will lead to breakthrough mechanistic understanding of how cells and tissues function at a fundamental molecular level, and serve as valuable resources for the broader research community. Ultimately, our team aims to translate this basic knowledge into novel diagnostic and therapeutic tools, with an emphasis on cancer, cardiovascular disease and neurodegenerative disorders.
McComb, Mark, PhD – Assoc. Research Professor
Julian Kwan, PhD – Postdoctoral Associate (lab manager)
Pierre Havugimana, PhD – Research Scientist
Indranil Paul, PhD – Postdoctoral Associate
Weiwei Lin, PhD – Postdoctoral Associate
Benjamin Blum – Graduate student
Matthew Lawton – Graduate Student
Isabella Turcinovic – Undergraduate Assistant
Christian Heckendorf, MSc – Senior Analyst
Fei Bian, PhD – Visiting Scientist
Kieran Wynne – Research Associate
- Rodionova IA, Goodacre N, Babu M, Emili A, Uetz P, Saier MH. The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. J Bacteriol. 2018 Mar 01; 200(5). PMID: 29229699.
Pourhaghighi R, Emili A. Global Characterization of Protein Complexes by Biochemical Purification-Mass Spectrometry (BP/MS). Methods Mol Biol. 2018; 1764:185-191. PMID: 29605916.
Goebels F, Hu L, Bader G, Emili A. Automated Computational Inference of Multi-protein Assemblies from Biochemical Co-purification Data. Methods Mol Biol. 2018; 1764:391-399. PMID: 29605929.
Yoon C, Song H, Yin T, Bausch-Fluck D, Frei AP, Kattman S, Dubois N, Witty AD, Hewel JA, Guo H, Emili A, Wollscheid B, Keller G, Zandstra PW. FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors. Stem Cell Reports. 2018 Jan 09; 10(1):87-100. PMID: 29249665.
Sandhu C, Qureshi A, Emili A. Panomics for Precision Medicine. Trends Mol Med. 2018 Jan; 24(1):85-101. PMID: 29217119.
Babu M, Bundalovic-Torma C, Calmettes C, Phanse S, Zhang Q, Jiang Y, Minic Z, Kim S, Mehla J, Gagarinova A, Rodionova I, Kumar A, Guo H, Kagan O, Pogoutse O, Aoki H, Deineko V, Caufield JH, Holtzapple E, Zhang Z, Vastermark A, Pandya Y, Lai CC, El Bakkouri M, Hooda Y, Shah M, Burnside D, Hooshyar M, Vlasblom J, Rajagopala SV, Golshani A, Wuchty S, F Greenblatt J, Saier M, Uetz P, F Moraes T, Parkinson J, Emili A. Global landscape of cell envelope protein complexes in Escherichia coli. Nat Biotechnol. 2018 Jan; 36(1):103-112. PMID: 29176613.
Mahadevan V, Khademullah CS, Dargaei Z, Chevrier J, Uvarov P, Kwan J, Bagshaw RD, Pawson T, Emili A, De Koninck Y, Anggono V, Airaksinen M, Woodin MA. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. Elife. 2017 Oct 13; 6. PMID: 29028184.
Guo H, Peng H, Emili A. Mass spectrometry methods to study protein-metabolite interactions. Expert Opin Drug Discov. 2017 Dec; 12(12):1271-1280. PMID: 28933205.
Havugimana PC, Hu P, Emili A. Protein complexes, big data, machine learning and integrative proteomics: lessons learned over a decade of systematic analysis of protein interaction networks. Expert Rev Proteomics. 2017 Oct; 14(10):845-855. PMID: 28918672.
Guo H, Isserlin R, Emili A, Burniston JG. Exercise-responsive phosphoproteins in the heart. J Mol Cell Cardiol. 2017 Oct; 111:61-68. PMID: 28826663.
- Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, Sharma P, Gramolini AO, Emili A. Proc Natl Acad Sci U S A (2016) 113(44):12592-12597. PMID: 27742792
- Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery. Gagarinova A, Stewart G, Samanfar B, Phanse S, White CA, Aoki H, Deineko V, Beloglazova N, Yakunin AF, Golshani A, Brown ED, Babu M, Emili A. Cell Rep (2016) 17(3):904-916. PMID: 27732863
Complete list can be found at BU Profiles