• Title Professor of Biochemistry and Biology
    Director, Center for Network Systems Biology
  • Education PhD: Molecular Biology, University of Toronto
  • Office K3
  • Phone 617-358-4511
  • Area of Interest Molecular Interaction Networks, Precision Mass Spectrometry, Proteomics, Functional Genomics, Bioinformatics, Systems Biology

Charting the molecular networks of cells and tissues
My laboratory develops and applies advanced proteomic, molecular genetic, genomic and bioinformatic technologies to investigate the molecular associations and biological roles of the many varied macromolecules present in different cells, tissues and organisms. Our research team has outstanding skills in state-of-the-art protein mass spectrometry and other high-throughput techniques for investigating molecular interaction networks in a global systems-wide manner. Our group aims to generate comprehensive maps of the physical and functional “interactomes” of informative models, ranging from unicellular microbes like yeast or the bacterium E. coli to more complex metazoans such as worm, mouse and (increasingly) human. We expect these maps will lead to breakthrough mechanistic understanding of how cells and tissues function at a fundamental molecular level, and serve as valuable resources for the broader research community. Ultimately, our team aims to translate this basic knowledge into novel diagnostic and therapeutic tools, with an emphasis on cancer, cardiovascular disease and neurodegenerative disorders.

Benjamin Blum – Graduate student
Julian Kwan (PhD) – Postdoctoral Associate (lab manager)
Pierre Havugimana (PhD) – Research Scientist
Matthew Lawyon – Graduate Student
Indranil Paul (PhD) – Postdoctoral Associate
Kieran Wynne – Research Associate

  1. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, Sharma P, Gramolini AO, Emili A. Proc Natl Acad Sci U S A (2016) 113(44):12592-12597. PMID: 27742792
  2. Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery. Gagarinova A, Stewart G, Samanfar B, Phanse S, White CA, Aoki H, Deineko V, Beloglazova N, Yakunin AF, Golshani A, Brown ED, Babu M, Emili A. Cell Rep (2016) 17(3):904-916. PMID: 27732863
  3. An Unbiased Chemical Proteomics Method Identifies FabI as the Primary Target of 6-OH-BDE-47. Peng H, Guo H, Pogoutse O, Wan C, Hu LZ, Ni Z, Emili A. Environ Sci Technol (2016) 50(20):11329–11336 PMID: 27682841
  4. G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis. Olsen JB, Wong L, Deimling S, Miles A, Guo H, Li Y, Zhang Z, Greenblatt JF, Emili A*, Tropepe V*. Stem Cell Reports (2016) 7(3):454-70. PMID: 27546533
  5. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V. Genes Dev (2016) 30(24):2696-2709. PMID: 28087714.
  6. Simple and Effective Affinity Purification Procedures for Mass Spectrometry-Based Identification of Protein-Protein Interactions in Cell Signaling Pathways. Kwan JHM, Emili A. Methods Mol Biol (2016) 1394:181-187. PMID: 26700049
  7. Investigating Bacterial Protein Synthesis Using Systems Biology Approaches. Gagarinova A, Emili A. Adv Exp Med Biol (2015) 883:21-40. PMID: 26621460
  8. Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics. Hadley KC, Rakhit R, Guo H, Sun Y, Jonkman JE, McLaurin J, Hazrati LN, Emili A, Chakrabartty A. Elife (2015) 4:e09579. PMID: 26418743
  9. Panorama of ancient metazoan macromolecular complexes. Wan C, Borgeson B, Phanse S, Tu F, Drew K, Clark G, Xiong X, Kagan O, Kwan J, Bezginov A, Chessman K, Pal S, Cromar G, Papoulas O, Ni Z, Boutz DR, Stoilova S, Havugimana PC, Guo X, Malty RH, Sarov M, Greenblatt J, Babu M, Derry WB, Tillier ER, Wallingford JB, Parkinson J, Marcotte EM, Emili A. Nature (2015) 525(7569):339-44. PMID: 26344197
  10. Phosphoproteomic network analysis in the sea urchin Strongylocentrotus purpuratus reveals new candidates in egg activation. Guo H, Garcia-Vedrenne AE, Isserlin R, Lugowski A, Morada A, Sun A, Miao Y, Kuzmanov U, Wan C, Ma H, Foltz K, Emili A. Proteomics (2015) 15(23-24):4080-95. PMID: 26227301

Complete list can be found at BU Profiles

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