Wande Li

Wande Li

Associate Research Professor
Department of Biochemistry

Boston University School of Medicine
Silvio Conte Building, Lab: K3; Office: K3
72 E. Concord Street
Boston, MA. 02118

Phone: 617-638-5485

Lab: 617-638-4823

Fax: 617-638-5339

Email: wandeli@bu.edu

Education:

MD, North China Coal Medical College, China

MS, Pathology, Zhejiang Medical University, China

Post-Doctor Fellow, Mallory Institute of Pathology, Boston City Hospital, and Department of Pathology, Boston University School of Medicine

Research Interests:

Lysyl oxidase (LO), a copper-(Cu) dependent enzyme, oxidizes peptidyl lysine residues in substrates, e.g., collagen, elastin and histone H1, essential for organization and stabilization of the extracellular matrix (ECM) and the cell nucleus. Abnormal LO expression is implicated in various pathological states such as organ fibrosis, atherosclerosis, emphysema, carcinogenesis, etc. Thus, LO as an intra- and extracellular effector plays a critical role in pathogenesis of matrix diseases and cancers. Cadmium (Cd) is a toxic heavy metal widely used in industries affecting human health. In addition to the occupational contamination, cigarette smoke constitutes a major source of Cd exposure for humans since tobacco leaves naturally accumulate Cd. Chronic exposure of humans to Cd induces emphysema and lung cancers. Previous studies by this lab investigating the phenotype change from Cd sensitive to Cd resistant of rat lung fibroblasts illustrated that in comparison to other Cu binding proteins, LO was specifically downregulated at mRNA, protein and catalytic levels following long term-Cd exposure. To assess the transcriptional regulation of LO, we have cloned and characterized the 5’-flanking region of the rat LO gene. Current studies in this lab focuses on investigating Cd modulation of LO transcription and posttranscription in cell and animal model, thus enhancing our understanding of molecular mechanisms for the pathogenesis of lung cancer and emphysema induced by Cd, and providing the basis for developing protective and therapeutic strategies for these common lung diseases.

Representative Publications: