Matthew D. Layne

Assistant Professor

Silvio Conte Building, Office K203, Lab K219
72 E. Concord Street
Boston, MA 02118

Phone: 617-638-4361
Lab Phone: 617-638-5926
Fax: 617-638-5339
Email:
Matthew Layne

Education

BA, Boston University, Boston, MA
PhD, Boston University, Boston, MA
Postdoctoral Training: Brigham and Women’s Hospital/Harvard Medical School

BU Profiles

People

Dahai Wang
Postdoctoral Associate
Mike Jager
Graduate Student
Joseph Phalan
Graduate Student

Former Members here

Teaching

Dr. Layne directs 2 graduate level courses:
GMS BI777 Techniques in Biochemistry, Cell, and Molecular Biology: More info here BI777
GMS FC762 Critical Thinking in Biomedical Research: More info here FC762

Research Interests

The primary goal of our laboratory is to identify novel pathways that control fibroproliferation with the goal of developing therapeutic inhibitors. Fibroproliferative responses are similar to wound healing processes involving accumulation of contractile myofibroblasts and extracellular matrix (ECM) secretion. Because organ fibrosis, cardiovascular, metabolic/obesity, and cancer pathologies are now recognized to be impacted by fibroblast-myofibroblast differentiation and ECM remodeling our research is examining novel pathways and control mechanisms in these diseases. Central to our studies is determining the function of Aortic carboxypeptidase-like Protein (ACLP), a secreted, collagen-binding protein that enhances fibrosis and myofibroblast differentiation through mechanisms that involve stimulating the transforming growth factor β (TGFβ) receptor signaling complex and controlling mechanical signaling and ECM remodeling.

ACTIVE RESEARCH PROJECTS:

1. Regulation of vascular smooth muscle cell and adventitial fibroblast differentiation and remodeling.

2. Control of lung and skin fibrosis.

3. Development of tumor stroma directed therapies.

4. Regulation of adipose stem cell differentiation and adipose tissue fibrosis.

Research Themes

Inflammation & ECM
Obesity & Metabolism
Cell Biology & Cancer

Representative Publications

PubMed Search