Emergency BU Alert BU Medical Campus OPEN Jan. 28, 2015 Boston University Medical Campus will be open Wednesday, Jan. 28, 2015. BUSM classes will be held as scheduled. Staff should check with their managers regarding work schedules. Medical, PA and GMS students who are assigned to inpatient services or clinics are expected to be present, if possible. Students who are assigned to outpatient services should check with their course director or the policy at the clinical site. GMS classes are canceled. Staff should check with their manager regarding their work schedules. The Henry M. Goldman School of Dental Medicine will follow normal school hours. All Patient Treatment Centers will be open for patient care and all classes will be held as scheduled. BU School of Public Health classes are canceled; SPH non-essential staff may telecommute. Employees who are part of the BUMC parking program should park in your assigned lot or garage. The Boston parking ban is still in effect. For updated information, please call the weather/emergency hotline at 617-638-6886 or visit the BU Emergency Communications website at http://www.bu.edu/ehs/comm/

Matthew D. Layne

layne.facultyAssistant Professor

Silvio Conte Building, Office K203, Lab K219
72 E. Concord Street
Boston, MA 02118

Phone: 617-638-4361
Lab Phone: 617-638-5926
Fax: 617-638-5339
Email:
Matthew Layne

Education

BA, Boston University, Boston, MA
PhD, Boston University, Boston, MA
Postdoctoral Training: Brigham and Women’s Hospital/Harvard Medical School

BU Profiles

People

Dahai Wang
Postdoctoral Associate
Mike Jager
Graduate Student
Joseph Phalan
Graduate Student

Former Members here

Teaching

Dr. Layne directs 2 graduate level courses:
GMS BI777 Techniques in Biochemistry, Cell, and Molecular Biology: More info here BI777
GMS FC762 Critical Thinking in Biomedical Research: More info here FC762

Research Interests

The primary goal of our laboratory is to identify novel pathways that control fibroproliferation with the goal of developing therapeutic inhibitors. Fibroproliferative responses are similar to wound healing processes involving accumulation of contractile myofibroblasts and extracellular matrix (ECM) secretion. Because organ fibrosis, cardiovascular, metabolic/obesity, and cancer pathologies are now recognized to be impacted by fibroblast-myofibroblast differentiation and ECM remodeling our research is examining novel pathways and control mechanisms in these diseases. Central to our studies is determining the function of Aortic carboxypeptidase-like Protein (ACLP), a secreted, collagen-binding protein that enhances fibrosis and myofibroblast differentiation through mechanisms that involve stimulating the transforming growth factor β (TGFβ) receptor signaling complex and controlling mechanical signaling and ECM remodeling.

ACTIVE RESEARCH PROJECTS:

1. Regulation of vascular smooth muscle cell and adventitial fibroblast differentiation and remodeling.

2. Control of lung and skin fibrosis.

3. Development of tumor stroma directed therapies.

4. Regulation of adipose stem cell differentiation and adipose tissue fibrosis.

Research Themes

Inflammation & ECM
Obesity & Metabolism
Cell Biology & Cancer

Representative Publications

PubMed Search