Matthew D. Layne

Assistant Professor

Silvio Conte Building, Office K203, Lab K219
72 E. Concord Street
Boston, MA 02118

Phone: 617-638-4361
Lab Phone: 617-638-5926
Fax: 617-638-5339
Matthew Layne


BA, Boston University, Boston, MA
PhD, Boston University, Boston, MA
Postdoctoral Training: Brigham and Women’s Hospital/Harvard Medical School

BU Profiles


Dahai Wang
Postdoctoral Associate
Mike Jager
Graduate Student
Carl Ceraolo
Graduate Student
Anupama Tiwari
Postdoctoral Associate
Ana de la Cueva
Postdoctoral Associate

Former Members here


Dr. Layne directs 2 graduate level courses:
GMS BI777 Techniques in Biochemistry, Cell, and Molecular Biology: More info here BI777
GMS FC762 Critical Thinking in Biomedical Research: More info here FC762

Research Interests

The primary goal of our laboratory is to identify novel pathways that control fibroproliferation with the goal of developing therapeutic inhibitors. Fibroproliferative responses are similar to wound healing processes involving accumulation of contractile myofibroblasts and extracellular matrix (ECM) secretion. Because organ fibrosis, cardiovascular, metabolic/obesity, and cancer pathologies are now recognized to be impacted by fibroblast-myofibroblast differentiation and ECM remodeling our research is examining novel pathways and control mechanisms in these diseases. Central to our studies is determining the function of Aortic carboxypeptidase-like Protein (ACLP), a secreted, collagen-binding protein that enhances fibrosis and myofibroblast differentiation through mechanisms that involve stimulating the transforming growth factor β (TGFβ) receptor signaling complex and controlling mechanical signaling and ECM remodeling.


1. Regulation of vascular smooth muscle cell and adventitial fibroblast differentiation and remodeling.

2. Control of lung and skin fibrosis.

3. Development of tumor stroma directed therapies.

4. Regulation of adipose stem cell differentiation and adipose tissue fibrosis.

Research Themes

Cell Biology
Inflammation & ECM

Representative Publications

PubMed Search