Matthew D. Layne

Assistant Professor

Silvio Conte Building, Office K203, Lab K219
72 E. Concord Street
Boston, MA 02118

Phone: 617-638-4361
Lab Phone: 617-638-5926
Fax: 617-638-5339
Email:
Matthew Layne

Education

BA, Boston University, Boston, MA
PhD, Boston University, Boston, MA
Postdoctoral Training: Brigham and Women’s Hospital/Harvard Medical School

People

Dahai Wang
Postdoc
Mike Jager
Graduate Student
Kathleen Tumelty
Graduate Student

Former Members here

Research Interests

Dr. Layne established his laboratory in the Biochemistry Department at Boston Univeristy Medical School in the summer of 2007.

Our long-term goals are to understand the transcriptional control of genes, which are upregulated in the vascular smooth muscle cells and fibroblasts in cardiovascular and pulmonary disease. We have identified a secreted protein, aortic carboxypeptidase-like protein (ACLP), which contains a collagen-binding discoidin and a catalytically inactive metallocarboxypeptidase domain. ACLP is expressed in vascular smooth muscle cells and is induced in the diseased blood vessel in vivo. We are defining the mechanisms by which ACLP regulates VSMC proliferation and function using in vitro assays and vascular disease models with transgenic and knockout mice. The lab is also investigating the control of myofibroblast gene expression in pulmonary fibrosis. We are exploring the mechanisms of gene expression and differentiation mechanisms in myofibroblasts and have identified novel signaling pathways and regulatory pathways that may coordinate the expression and subsequent deposition of extracellular matrix proteins in wounded VSMC and fibroblasts.

Current Projects:

  1. Investigating the regulation of genes in vascular smooth muscle cells in response to injury
  2. Determining the role of aortic carboxypeptidase-like protein in vascular smooth muscle biology
  3. Defining mechanism of fibroblast/myofibroblast transitions in fibrotic disease

Research Themes

ECM/Cellular Injury

Metabolism, Obesity/Diabetes

Signal Transduction & Cancer

Representative Publications

PubMed Search