Konstantin V. Kandror

Professor

Boston University School of Medicine
Silvio Conte Building, K120D
72 E. Concord Street
Boston, MA 02118

Phone: 617-638-5049
Lab Phone:
 617-638-5068
Fax:
617-638-5339
Email:
kkandror@bu.edu

Education

BS, MS, Moscow State University, Moscow, Russia
PhD, Bakh Institute of Biochemistry, Moscow, Russia

BU Profile

People

Maneet Singh
Postdoctoral Fellow
Xiaoqing Yang
Postdoctoral Fellow

Research Interests

Adipocytes, skeletal myocytes and some neurons express a specific isoform of the glucose transporter protein, Glut4. Under basal conditions this transporter is localized in intracellular membrane vesicles which fuse with the plasma membrane upon insulin administration. Translocation of Glut4 plays a major role in post-prandial glucose clearance and, more generally, in glucose sensing and metabolic homeostasis in the body. For a number of years, my lab has been involved in the dissection of the “Glut4 pathway” in various insulin-sensitive cells.

kandrorlab

Another key physiological function of insulin is to inhibit lipolysis and to promote storage of triglycerides in fat tissue. Recently, we have discovered two novel pathways of regulation of lipolysis by insulin. One of these pathways is mediated by the insulin- and nutrient-sensitive mammalian Target of Rapamycin Complex 1, while the other is mediated by transcriptional factor FoxO1. Currently, we are engaged in the dissection of both pathways at the molecular level.

Fat represents an important secretory tissue in the body. Unlike typical endocrine and exocrine cells, adipocytes produce and secret several physiologically important proteins, such as leptin, adiponectin, lipoprotein lipase, etc. and switch the secretory process from one protein to another in response to changing metabolic conditions. We are exploring connections between food intake, obesity and secretion of adipokines in order to understand the central role of fat tissue in the orchestrating the overall response of the organism to changing metabolic conditions.

Research Themes

Obesity & Metabolism

Recent Publications
PubMed