Abraham Lab

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Boston University School of Medicine
Silvio Conte Building, Lab K304
72 E. Concord Street
Boston, MA 02118

Lab Phone: 617-638-4315

Current Projects:

Alzheimer’s disease and Multiple Sclerosis:

  • Identifying the mechanism by which modulating amyloid precursor protein (APP) dimerization leads to lowering of the toxic amyloid beta peptide (Aß) formation
  • Determine the role of Klotho in AD and MS mouse models using Klotho overexpressing mice

Normal aging of the brain:

  • Decipher the protective function of the anti aging protein Klotho in the brain, focusing on neurons and oligodendrocytes
  • Identify the Klotho receptor and its signaling pathway
  • Evaluate how various human polymorphisms in Klotho affect its intracellular trafficking, secretion and function

Translational Neuroscience:

  • Optimize Aß-lowering compounds identified in a high throughput screen (HTS) to find inhibitors of APP dimerization for future pre-clinical trials
  • Optimize Klotho enhancing compounds identified in a HTS for testing in animal models of AD and MS

Opportunities:

Interested graduate students should contact Dr. Abraham regarding the availability of research rotations.

Contact:

Carmela Abraham, PhD
Boston University School of Medicine
Department of Biochemistry, K304
72 E. Concord Street
Boston, MA 02118
cabraham@bu.edu