Abraham Lab

Boston University School of Medicine
Silvio Conte Building, Lab K304
72 E. Concord Street
Boston, MA 02118

Lab Phone: 617-638-4315

Alzheimer’s disease:

Understand the role of amyloid precursor protein (APP) dimerization in amyloid beta peptide (Aß) formation
Determine the role of Klotho in AD models by crossing AD mice with Klotho mice

Normal aging of the brain:

Decipher the protective function of the anti aging protein Klotho in the brain
Identify the Klotho receptor and its signaling pathway
Evaluate how various polymorphisms in Klotho affect its intracellular trafficking and secretion
Examine the role of the aberrant fragmentation of the oligodendrocytic protein CNPase in the myelin degeneration seen in aged rhesus monkeys

Translational Neuroscience:

Optimize Aß-lowering compounds identified in a high throughput screen (HTS) to find inhibitors of APP dimerization for future pre-clinical trials
Optimize Klotho enhancing compounds identified in a HTS for testing in animal models

Opportunities:

Interested graduate students should contact Dr. Abraham regarding the availability of research rotations.

Contact:

Carmela Abraham, PhD
Boston University School of Medicine
Department of Biochemistry, K304
72 E. Concord Street
Boston, MA 02118
cabraham@bu.edu