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Abraham Lab


Boston University School of Medicine
Silvio Conte Building, Lab K304
72 E. Concord Street
Boston, MA 02118

Lab Phone: 617-638-4315

Current Projects:

Alzheimer’s disease and Multiple Sclerosis:

  • Identifying the mechanism by which modulating amyloid precursor protein (APP) dimerization leads to lowering of the toxic amyloid beta peptide (Aß) formation
  • Determine the role of Klotho in AD and MS mouse models using Klotho overexpressing mice

Normal aging of the brain:

  • Decipher the protective function of the anti aging protein Klotho in the brain, focusing on neurons and oligodendrocytes
  • Identify the Klotho receptor and its signaling pathway
  • Evaluate how various human polymorphisms in Klotho affect its intracellular trafficking, secretion and function

Translational Neuroscience:

  • Optimize Aß-lowering compounds identified in a high throughput screen (HTS) to find inhibitors of APP dimerization for future pre-clinical trials
  • Optimize Klotho enhancing compounds identified in a HTS for testing in animal models of AD and MS


Interested graduate students should contact Dr. Abraham regarding the availability of research rotations.


Carmela Abraham, PhD
Boston University School of Medicine
Department of Biochemistry, K304
72 E. Concord Street
Boston, MA 02118