Irina V. Zhdanova, MD, Ph.D.


Phone: 617-638-8002
Fax: 617-638-4676
Location: R – 913, BUSM.

Lab: The Laboratory of Sleep & Circadian Physiology
CV: Irina Zhdanova, M.D., Ph.D.– CV

Dr. Zhdanova received her MD in Internal Medicine from the 1st Leningrad Medical Institute and has specialized in Clinical Physiology. She then received her PhD in Physiology of Behavior from the Institute of Experimental Medicine (St. Petersburg Russia). She completed her post-doctoral training at the Institute of Physiology (FIN), Russian Academy of Sciences, and then at the Massachusetts Institute of Technology (MIT).

Dr. Zhdanova is studying the role of circadian system in development and aging, and an impact of circadian factors on the effects of drugs of abuse. The studies in her laboratory employ non-human primates and zebrafish.

Dr. Zhdanova teaches in the Neuroscience course offered in the Medical School (AN703), Cognitive Neuroscience and Behavioral Neuroscience graduate courses. Starting Spring 2016, she directs and teaches a course on Sleep and Circadian Rhythms.

Dr. Zhdanova is a member of the Department Qualifying Exam Committee (Chair) and the Medical School Executive Committee of the Cell and Molecular Biology program.


Recent Publications

Shang EH, Zhdanova IV. (2007) The circadian system is a target and modulator of prenatal cocaine effects. PLoS ONE. Jul 11;2(7):e587.

Sack RL; Auckley D; Auger RR; Carskadon MA; Wright KP; Vitiello MV; Zhdanova IV. Circadian rhythm sleep disorders: Part I, basic principles, shift work and jet lag disorders. SLEEP 2007; Nov 1;30(11):1460-83.

Sack R; Auckley D; Auger RR; Carskadon MA; Wright KP; Vitiello MV; Zhdanova IV. (2007) Circadian rhythm sleep disorders: Part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. SLEEP;Nov 1;30(11):1484-501.

Lopez-Patino MA, Yu L, Cabral H, Zhdanova IV. (2008) Anxiogenic effects of cocaine withdrawal in zebrafish. Physiol Behav. Jan 28;93(1-2):160-71

Zhdanova IV, Yu L, Lopez-Patino M, Shang E, Kishi S, Guelin E (2008) Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance  Brain Res Bull  75(2-4): 433-441.

López Patiño MA, Yu L, Yamamoto BK, Zhdanova IV. (2008) Gender differences in zebrafish responses to cocaine withdrawal. Physiol Behav. 95(1-2):36-47

Kishi S, Slack BE, Uchiyama J, Zhdanova IV. (2009) Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates. Gerontology. 55(4):430-41.

Masuda K., Zhdanova IV (2010) The intrinsic activity rhythms in Macaca mulatta, their entrainment to light and melatonin. Journal of Biological Rhythms. 25:361-371.

Zhdanova IV (2011) Sleep and its regulation in zebrafish. Reviews in the Neurosciences 22(1) 27-36

Zhdanova, IV, Masuda K, Quasarano-Kourkoulis C, Rosene DL, Killiany RJ, Wang S. (2011) Aging of intrinsic circadian rhythms and sleep in a diurnal non-human primate, Macaca mulatta. Journal of Biological Rhythms J Biol Rhythms. 26(2):149-59.

Zhdanova IV, Masuda K , Bozhokin SV , Rosene DL , González-Martínez J , et al. (2012) Familial Circadian Rhythm Disorder in the Diurnal Primate, Macaca mulatta. PLoS ONE 7(3): e33327.

Akle V., Guelin E., Yu, L., Brassard H., Slack BE, Zhdanova IV. (2012) F-spondin/spon1b expression patterns in developing and adult zebrafish. PLoS One 7(6):e37593

Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N. (2013) Lysine methylation promotes VEGFR-2 activation and angiogenesis. Science Signal. Dec 3;6(304):ra104.