Donald F. Siwek, Ph.D.

siwekAssistant Professor

Phone: 617 638-5992
Fax: 617 638-5863

Location: M-902, Solomon Carter Fuller Bldg, BUSM

Dr. Siwek received his doctorate from Boston University in 1989. His dissertation included a study of the topography of the connections between the prefrontal cortex and the mediodorsal nucleus of the thalamus in the rhesus monkey. Immediately following this he received a National Research award from the National Eye Institute. He spent 3 years in the laboratory of Dr. Bertram Payne, learning techniques in neurophysiology and studying the nature of trans-callosal connections in the cat visual system. Dr. Siwek worked at the Research Service of the Veterans Administration Hospital in Bedford, MA beginning in 1991. His work there included the neurophysiology of neurons in brain slices of the auditory cortex of the rat. He was the Data Manager for the Boston University Alzheimer’s Disease Center from 1995 to 2000. In 2000, he joined the Neuroanatomy core of a multidisciplinary program project study looking at the effects of perinatal diet on brain development and aging. Today Dr. Siwek is the Assistant Director of the Laboratory of Sleep and Cognitive Neurobiology at BUSM, The present focus of their work is on the neurobiology of sleep in the rat. They are exploring the initiation and maintenance of sleep is studied using state of the art techniques in electrophysiology, behavior, pharmacology, molecular biology and anatomy.

Recent Publications

Datta S, Siwek DF, Huang MP. (2009) Improvement of two-way active avoidance memory requires protein kinase a activation and brain-derived neurotrophic factor expression in the dorsal hippocampus. J Mol Neurosci. Jul;38(3):257-64.

Datta S, Siwek DF, Stack EC. (2009) Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleep. Neuroscience. 2009 Jun 18. [Epub ahead of print]

Klivenyi P, Siwek D, Gardian G, Yang L, Starkov A, Cleren C, Ferrante RJ, Kowall NW, Abeliovich A, Beal MF. Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiol Dis. 2006 Mar;21(3):541-8. Epub 2005 Nov 18.